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Methylene blue trihydrate (7220-79-3)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0025600


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Equivocal Evidence, Female, Mice
  • Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Methylene blue trihydrate (7220-79-3).
Micronucleus - Mice
View
  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Methylene blue trihydrate (7220-79-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methylene blue trihydrate (7220-79-3).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive

Citation Information


NTP. Methylene blue trihydrate (7220-79-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-540 Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Final Report on the Developmental Toxicity of Methylene Blue Trihydrate in New Zealand White Rabbits
Final Report on the Developmental Toxicity of Methylene Blue Trihydrate in New Zealand White Rabbits
Final Report on the Developmental Toxicity of Methylene Blue Trihydrate in Sprague-Dawley (CD) Rats

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C91005) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
18-33 Day Evaluation of the Toxicity (C91005) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in F344 Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C91005B) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C91005C) of Methylene Blue Trihydrate (7220-79-3) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Methylene Blue Trihydrate (7220-79-3) in Micronucleus Study A76244 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methylene Blue Trihydrate (7220-79-3) in Micronucleus Study A77225 in B6C3F1 Mice
Genetic Toxicity Evaluation of Methylene Blue Trihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 811345
Summary Data
Genetic Toxicity Evaluation of Methylene Blue Trihydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35880
Summary Data

Other NTP Studies


Prenatal Developmental Toxicity Study (TER92124) of Methylene Blue Trihydrate (7220-79-3) in Sprague-Dawley Rats Exposed via Gavage
Prenatal Developmental Toxicity Study (TER92125) of Methylene Blue Trihydrate (7220-79-3) in New Zealand White Rabbits Exposed via Gavage