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2,4-Diaminotoluene (95-80-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID4020402


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Negative, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 2,4-Diaminotoluene (95-80-7).
Micronucleus - Mice
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  • Male: Negative
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,4-Diaminotoluene (95-80-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,4-Diaminotoluene (95-80-7).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 2,4-Diaminotoluene (95-80-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-162 Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Female B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Micronucleus Study 520516 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in Micronucleus Study 571690 in B6C3F1 Mice
Genetic Toxicity Evaluation of 2,4-Diaminotoluene (2,4-Toluene Diamine) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 707834
Summary Data

Other NTP Studies


14-Day Immunotoxicity Evaluation (IMM87034) of 2,4-Diaminotoluene (2,4-Toluene Diamine) (95-80-7) in B6C3F1 Mice via Gavage
2-Week Immunotoxicity Evaluation (IMM86001) of Toluenes (2-4-Diaminotoluene, p-Nitrotoluene, 4-Chloro-o-Phenylenediamine) (TOLUENES) in Female B6C3F1 Mice Exposed via Gavage