National Toxicology Program

National Toxicology Program

Nominate to NTP

NTP welcomes nominations of agents/models for consideration and evaluation by the Program. You can nominate an agent or model to one of five areas. If you are unsure of the proper area, nominate it to NTP's Testing Program.

NTP's Testing Program

NTP maintains an open nomination process. Chemicals may be studied for a variety of health-related effects, including but not limited to, reproductive and developmental toxicity, genotoxicity, immunotoxicity, metabolism and disposition, as well as carcinogenicity. The possible public health consequences of exposure remain the overriding factor in the decision to study a particular chemical or agent.

Nominate to the NTP Testing Program

Office of the Report on Carcinogens (ORoC)

The Report on Carcinogens is a report prepared by NTP which contains a list of all substances which either are known to be carcinogens [in humans] or may reasonably be anticipated to be [human] carcinogens; and to which a significant number of persons residing in the United States are exposed.

Nominations must contain a rationale for listing or delisting as either a "known human carcinogen" or a "reasonably anticipated human carcinogen." Appropriate background information and relevant data (e.g., journal articles, NTP Technical Reports, IARC listings, exposure surveys, release inventories, etc.) that support the nomination should be provided or referenced when possible.

Nominate to ORoC

Office of Health Assessment and Translation (OHAT)

The Office of Health Assessment and Translation (OHAT), established in 2011, serves as an environmental health resource to the public and to regulatory and health agencies. OHAT conducts technical assessments focused on understanding the potential for adverse effects on human health by agents, substances, mixtures, or exposure circumstances (collectively referred to as substances).

Nominations must be accompanied by the reason for the nomination and, whenever possible, appropriate background information, data, or literature citations.

Nominate to OHAT

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

NICEATM provides support to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM is made up of representatives of 15 U.S. Federal agencies who work together to facilitate development, validation and regulatory acceptance of new and revised regulatory test methods that reduce, refine, and replace the use of animals in testing while maintaining and promoting scientific quality and the protection of human health, animal health, and the environment. As part of that mission, ICCVAM evaluates test methods for their usefulness for a specific proposed regulatory requirement or application. Nominations of test methods for ICCVAM evaluation are administered by NICEATM. Read more about nominations to ICCVAM .

Nominate to NICEATM

High Throughput Screening Initiative

The NTP Biomolecular Screening Branch accepts nominations of high throughput or high content screens for possible use in NTP's High Throughput Screening (HTS) initiative. Nominations might include assays suitable for quantitative HTS investigations at the NIH Chemical Genomics Center (NCGC) in Rockville, MD, as well as those that may have lower throughput, but are informative on mechanism of action. NTP also welcomes the nomination of assays for follow-up testing of subsets of compounds to further define cellular pathways or confirm activity using an independent assay that measures the same endpoint. Of particular interest to NTP, both as primary and secondary screens, are assays, technologies, or methods that will aid the identification of compounds that are active only after metabolic activation. To nominate an assay, please complete and submit an Assay Nomination form. 

A detailed description of the protocol requirements for HTS assays to be considered for testing at the NCGC is available. A list of HTS-related publications that might be of interest is also available.

Nominate to the High Throughput Screening Initiative

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.