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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

Key NICEATM and ICCVAM Accomplishments and Impact

In 2013, Linda Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences (NIEHS) and the National Toxicology Program (NTP) announced that NIEHS would move forward with a different philosophy toward ICCVAM whereby the partner regulatory agencies would drive ICCVAM’s activities. At the same time, NICEATM would expand its scope to provide bioinformatic and computational toxicology support to the NIEHS Division of the NTP and its Biomolecular Screening Branch.

In 2014 and 2015, projects initiated under this new vision began to bear fruit, with potential impact on animal use worldwide.Some key accomplishments include:

NIEHS Director Linda Birnbaum, Ph.D., presenting NIEHS Merit Award to NICEATM staff.

Recognition for NICEATM and ICCVAM Accomplishments

NICEATM and EPA scientists developed an approach for detecting and measuring estrogen receptor bioactivity that relied on Tox21 and ToxCast data. This approach has been accepted as an alternative to tests required by the EPA Endocrine Disruptor Screening Program, the first accepted use of computational tools to replace a regulatory requirement for animal-based testing and a demonstration of the utility of Tox21 efforts. NICEATM staff were recognized for their contributions to this accomplishment in January 2016 with an NIEHS Merit Award.