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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

Acute Systemic Toxicity: DOD Activities

Report: Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense

The U.S. Department of Defense (DOD) needs the capability to screen chemicals and predict toxicity and threat status faster, more accurately, and with less reliance on animal use. To further this effort, DOD funded the National Academies of Sciences, Engineering, and Medicine to study how to use modern approaches to predict chemical toxicity. This resulted in the report “Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense.” The report reviews the current state of screening methods research and provides findings and recommendations related to these methods and their ability to predict toxicity of chemical threats. The report confirms that DOD could improve its predictive toxicity capability and reduce reliance on animal models; however, this will require further validation of the methods. A dedicated, multi-year investment strategy is needed. Subsequent to this report, DOD is developing an internal roadmap and reaching out to external organizations to discuss opportunities for strategic collaborations.

Report cover: