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ICCVAM Biennial Report 2014-2015

Biennial Progress Report 2014-2015 Interagency Coordinating Committee on the Validation of Alternative Methods

Acute Systemic Toxicity: EPA and NIEHS Activities

Use of Data From Oral Toxicity Tests to Determine Dermal Toxicity Hazard Classifications

Data from dermal systemic toxicity tests are used to determine appropriate hazard classification of pesticides and other substances. These categorizations in turn are used to develop product labels and define personal protective equipment requirements for occupational users. NICEATM scientists at the National Institute of Environmental Health Sciences are evaluating data from acute oral and dermal toxicity tests for over 200 pesticide active ingredients, including fungicides, herbicides, and insecticides. The goal is to determine whether data from oral toxicity tests could be used to assign U.S. Environmental Protection Agency (EPA) dermal hazard classifications and eliminate the need for separate acute dermal toxicity tests. Preliminary results presented in a poster (Paris et al.) at the 2015 Annual Meeting of the Society of Toxicology suggest that acute oral toxicity information may provide relevant information on dermal hazard and enable reduction of the number of animals used for dermal acute toxicity testing. The EPA will use a follow-up analysis of nearly 600 pesticide formulations, which produced similar results, to draft guidance for waiving acute dermal toxicity tests for pesticide formulations.