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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

Endocrine Disruptor Testing: EPA Activities

Update of EDSP Comprehensive Management Plan

The U.S. Environmental Protection Agency (EPA) updated the Comprehensive Management Plan (2014) for the Endocrine Disruptor Screening Program (EDSP) to emphasize the use of advanced informational technology and computational methods. The updated plan provides strategic guidance for agency personnel and outlines the critical EDSP activities that are planned over the next five years. Among these activities is a focus on using informational technology to enhance data interpretation and apply computational methods to more efficiently prioritize and screen chemicals in the EDSP for potential endocrine bioactivity.

Acceptance of High Throughput Screening Tests to Replace Current EDSP Tier 1 Tests

In a June 2015 Federal Register notice (80 FR 35350), EPA requested comments on a plan to accept ToxCast/Tox21 high throughput screening (HTS) assay data and an associated computational model as an alternative to three EDSP Tier 1 tests used to assess estrogen receptor activity. Described as “groundbreaking” in an EPA press release, the use of HTS assays and computational methods will accelerate the pace of screening, decrease costs, and reduce animal testing. The EPA approach was developed and validated by EPA and NICEATM scientists and is described in detail in a paper in Environmental Science and Technology.
More information about EPA’s use of high throughput assays and computational tools in EDSP