ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

Endocrine Disruptor Testing: ICCVAM and ICCVAM Agency Activities

Reference Data for In Vitro Androgen Receptor Assays

Using a list of putative androgen-active or inactive chemicals for which Tox21 or ToxCast data were available, NICEATM (National Institute of Environmental Health Sciences) performed a literature search to identify in vitro androgen receptor (AR) assay data. Posters describing the literature search were presented at the 2015 Annual Meeting of the American Society of Cellular and Computational Toxicology (Kleinstreuer et al.) and the 2015 Society of Toxicology FutureTox III meeting (Kleinstreuer et al.). In concert with this effort, the U.S. Environmental Protection Agency is conducting a literature search for in vivo assay data on androgenic activity on the same chemicals. ICCVAM established a working group in 2015 to review data from these literature searches with the goal of defining a list of reference chemicals and associated potencies for future validation of Tox21/ToxCast results and other novel AR assays.