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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

Research and Development: EPA Activities

ToxCast Program Activities

The ToxCast program generates data and predictive models on thousands of chemicals of interest to the U.S. Environmental Protection Agency (EPA). ToxCast uses HTS methods and computational toxicology approaches to rank and prioritize these chemicals for additional testing that may be needed to fully characterize their hazards. ToxCast program activities during 2014-2015 include:

  • Releases of reference data from animal toxicity studies (October 2014) and chemical information and assay results (October 2015)
  • Stakeholder workshops in January and April 2014 and the second ToxCast Data Summit in September 2014, which gave stakeholders opportunities to explore ToxCast data and tools and share applications of ToxCast data
  • Release of the Interactive Chemical Safety for Sustainability (iCSS) dashboard in September 2014, which provides an interactive tool to explore in vitro high throughput data generated by the ToxCast and Tox21 projects

Funding for Systems-Based Research for Evaluating Ecological Impacts of Manufactured Chemicals

In early 2014, EPA accepted applications for the funding opportunity “Systems-Based Research for Evaluating Ecological Impacts of Manufactured Chemicals.” Six grants were awarded to academic laboratories to support development and application of innovative methods and models to better understand biological and ecological consequences of exposure to chemicals. Awardees are developing adverse outcome pathway (AOP) models for effects of chemicals on aquatic species, allowing prediction of adverse effects and possible identification of safer alternatives.