COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.


ICCVAM Biennial Report 2014-2015

Biennial Progress Report 2014-2015 Interagency Coordinating Committee on the Validation of Alternative Methods

Research and Development: NIEHS Activities

Workshop on Good Cell Culture Practices for Induced Pluripotent Stem Cells

NICEATM (National Institute of Environmental Health Sciences [NIEHS]) co-organized the Workshop on Good Cell Culture Practices for Induced Pluripotent Stem Cells that was held in Baltimore in June 2015. The goal of this workshop was to develop consensus standards and foster international standardization on the use of induced pluripotent stem cells. Using existing standards for cell and tissue culture systems as a guide, the attendees considered the unique properties and challenges of pluripotent stem cells compared to traditional in vitro systems. Attendees then developed a framework for a guidance document specific to pluripotent stem cells that addresses quality of materials and methods, documentation, protection of workers and the environment from hazards, compliance with laws and ethical principles, and education and training. The guidance document will be submitted for publication in 2016.

Workshop on Adverse Outcome Pathways

NICEATM and the Physicians Committee for Responsible Medicine organized the workshop Adverse Outcome Pathways: From Research to Regulation. Plenary presentations that explained the adverse outcome pathway (AOP) concept and described case studies were followed by breakout sessions that considered AOP applications, development of new AOPs, and challenges to regulatory adoption of AOPs.

Systematic Evaluation of the Application of Zebrafish in NTP Toxicology Studies

NICEATM is part of an National Toxicology Program (NTP) effort, known as SEAZIT, to systematically evaluate the application of zebrafish in NTP toxicology studies. This effort will provide fundamental knowledge on the use of zebrafish in toxicology and support further research endeavors by the academic community.

Graphic from promotional materials for the AOP workshop

Workshop on Adverse Outcome Pathways

The workshop Adverse Outcome Pathways: From Research to Regulation was held in September 2014 at NIH. A report from the workshop will be submitted for publication in 2016.