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NICEATM (National Institute of Environmental Health Sciences [NIEHS]) co-organized the Workshop on Good Cell Culture Practices for Induced Pluripotent Stem Cells that was held in Baltimore in June 2015. The goal of this workshop was to develop consensus standards and foster international standardization on the use of induced pluripotent stem cells. Using existing standards for cell and tissue culture systems as a guide, the attendees considered the unique properties and challenges of pluripotent stem cells compared to traditional in vitro systems. Attendees then developed a framework for a guidance document specific to pluripotent stem cells that addresses quality of materials and methods, documentation, protection of workers and the environment from hazards, compliance with laws and ethical principles, and education and training. The guidance document will be submitted for publication in 2016.
NICEATM and the Physicians Committee for Responsible Medicine organized the workshop Adverse Outcome Pathways: From Research to Regulation. Plenary presentations that explained the adverse outcome pathway (AOP) concept and described case studies were followed by breakout sessions that considered AOP applications, development of new AOPs, and challenges to regulatory adoption of AOPs.
NICEATM is part of an National Toxicology Program (NTP) effort, known as SEAZIT, to systematically evaluate the application of zebrafish in NTP toxicology studies. This effort will provide fundamental knowledge on the use of zebrafish in toxicology and support further research endeavors by the academic community.