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On behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), we are pleased to present the 2014-2015 ICCVAM Biennial Progress Report. This report describes activities of ICCVAM and its 15 member agencies that support the ICCVAM mission of facilitating development, validation, and regulatory acceptance of new testing approaches.
In 2013, ICCVAM advanced a new philosophy under which its activities were to be driven by member agency needs and to better reflect the current direction of the science of toxicology. This report describes outcomes of activities begun under this new philosophy and the significant strides being made. A collaboration between NICEATM and the U.S. Environmental Protection Agency, an ICCVAM member agency, has led to U.S. acceptance of a computational approach that provides a non-animal replacement for a required test. ICCVAM also advanced non-animal testing approaches to identify skin sensitizers. These approaches have the potential to be used by multiple U.S. agencies, and ICCVAM regulatory agencies are currently working with their international counterparts to harmonize testing requirements so that these approaches can be adopted worldwide.
ICCVAM continues to work with NICEATM on outreach efforts, both to raise awareness of available alternative methods and to foster partnerships with stakeholders to maximize efficiency of development, validation, and implementation of new methods. During 2014 and 2015, ICCVAM convened two Public Forum meetings and participated in two public meetings of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM). The Public Forums were each viewed by over 100 webcast viewers and generated productive interactions between ICCVAM representatives and stakeholders. These meetings provided opportunities for ICCVAM agency representatives to present updates on activities, which then allows the SACATM meetings to be a forum for substantive strategic and technical discussions to better leverage the expertise of the SACATM members in advancing the ICCVAM mission. Additionally, in January 2015, ICCVAM presented its first Communities of Practice webinar featuring expert presentations on a current topic in alternative methods development. Interest in this webinar, which attracted over 250 viewers worldwide, prompted organization of a subsequent webinar series and workshop.
At the end of 2015, for the first time since ICCVAM was established, we began to define a process to add a new member agency to the committee. The National Institute of Standards and Technology will bring expertise and interest in measurement science and method validation to ICCVAM’s activities. We look forward to their participation in ICCVAM.
We gratefully acknowledge the contributions of the representatives and interagency working group members from the 15 ICCVAM member agencies. We also acknowledge the contributions from NICEATM and its contract staff, the members of SACATM, and our many other stakeholders.
The activities summarized in this report exemplify ICCVAM’s ongoing commitment to working with U.S. and international partners to advance the development and acceptance of new scientifically valid test methods that will reduce and eventually replace animal use. We look forward to continued progress and effective interactions with our stakeholders in the coming years.
Abigail Jacobs, Ph.D., Fellow ATS
Center for Drug Evaluation and Research
U.S. Food and Drug Administration
Anna Lowit, Ph.D.
Office of Pesticide Programs within the
Office of Chemical Safety and Pollution Prevention
U.S. Environmental Protection Agency
Warren Casey, Ph.D., DABT
Administrative Director, ICCVAM
National Institute of Environmental Health Sciences