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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015

ICCVAM Participation at National and International Meetings

NICEATM and ICCVAM scientists participated in a number of workshops, conferences, and meetings in 2014 and 2015. Brief descriptions of selected events are listed in the table below. References for poster presentations and some platform presentations are listed on the Biennial Report publications page.

Please note that any conclusions and recommendations issued in the proceedings of the meetings outlined below are those of the meeting participants. The inclusion of these conclusions and recommendations in this report should not be interpreted as an endorsement by ICCVAM or any of its member agencies.

hidden (sort issue) Meeting Date and Location Sponsoring Organization Meeting Title and Description Summary of ICCVAM or ICCVAM Agency Activity
  Jan.16-17, 2014
Chapel Hill, North Carolina
Society of Toxicology FutureTox II: Pathways to Prediction

The Society of Toxicology (SOT) organized the FutureTox meeting series to address the topic of transforming 21st century science into risk assessment and regulatory decision-making.
NICEATM scientists contributed to five posters describing use of high throughput screening data and computational methods to predict endocrine activity and skin sensitization potential of chemicals. A report of the workshop was published in February 2015 in Toxicological Sciences.
  Feb. 27, 2014
Somerset, New Jersey
New Jersey Association of Biomedical Research 3Rs Sharing Conference

This conference focused on the topic “Paving the Path to Regulatory Acceptance of Alternative Methods: Facilitating the Integration of Alternative Methods Into the Regulatory Framework.” The conference included speakers from the pharmaceutical and chemical industries who presented case studies and strategies for effective safety testing using fewer animals.
NICEATM Director Warren Casey, Ph.D., presented the keynote address, “New Direction and Transformation of NICEATM and ICCVAM.”
  March 24-27, 2014
Phoenix, Arizona
Society of Toxicology 53rd Annual Meeting ICCVAM Co-chair Abby Jacobs, Ph.D., U.S. Food and Drug Administration (FDA), co-chaired a session on non-animal approaches to photosafety testing of pharmaceuticals. NICEATM and ICCVAM scientists contributed to 15 poster presentations describing non-animal, high throughput, and computational approaches to chemical safety assessment.
  Aug. 24-28, 2014
Prague, Czech Republic
World Congress on Alternatives and Animal Use in the Life Sciences Ninth World Congress on Alternatives and Animal Use in the Life Sciences NICEATM scientists presented nine posters and three talks on topics including development of curated reference databases and computational and high throughput approaches to chemical screening and toxicity. ICCVAM committee members from the National Institute of Environmental Health Sciences (NIEHS) and FDA co-chaired five sessions and gave six platform presentations.  
  Dec. 2-5, 2014
Arlington, Virginia
U.S. Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel

This panel, composed of experts from government and academia, provides independent scientific advice to EPA on a wide range of health and safety issues related to pesticides.
Casey and Nicole Kleinstreuer, Ph.D., senior staff computational toxicologist on the ILS NICEATM support contract, presented on the curation of a uterotrophic assay database and a plan for use of high throughput screening data to replace three Tier 1 tests of the Endocrine Disruptor Screening Program (EDSP). The EPA considered the panel’s feedback in its June 2015 proposal to replace three current EDSP Tier 1 tests with validated ToxCast/Tox21 high throughput assays and an associated computational model.
  Feb. 10-12, 2015
Baltimore, Maryland
OpenTox Association OpenTox USA 2015

The theme of this conference was “Driving the Big Science Challenge in Safety Forward.”
Kleinstreuer presented a summary of NICEATM activities supporting development of an integrated testing strategy for skin sensitization.
  March 22-26, 2015
San Diego, California
Society of Toxicology 54th Annual Meeting ICCVAM members from FDA, EPA, and NIEHS co-chaired four sessions, and Casey gave two platform presentations. NICEATM staff members were co-authors on 11 posters presented at the meeting, and ICCVAM members were co-authors on six posters describing alternative testing methods and strategies.
  April 2, 2015 and June 4, 2015
Washington, DC
National Research Council Meetings of the Committee on Incorporating 21st Century Science into Risk-Based Evaluations

This committee was established to provide recommendations on integrating new scientific approaches into risk-based evaluations.
At the April 2015 meeting, ICCVAM member Suzanne Fitzpatrick, Ph.D., presented the talk “Risk-Based Decision-Making at the FDA.” At the June 2015 meeting, Casey presented on “Validation Principles for Tox21.”
  April 21, 2015
Sacramento, California
California Environmental Protection Agency Department of Pesticide Regulation and Physicians Committee for Responsible Medicine Symposium on In Vitro Skin Sensitization

This symposium focused on advances in skin sensitization determination with in vitro and in silico models.
Kleinstreuer gave the presentation “Integrated Computational Approaches to the Assessment of Skin Sensitization Potential of Chemicals.”
  June 23-26, 2015
Jeju City, South Korea
Asian Society of Toxicology ASIATOX 2015 International Congress

This is a triennial international congress held to facilitate and encourage scientific exchange and leadership.
Casey gave the presentation “Advances in the Development and Validation of Test Methods in the United States.”
  June 27-July 1, 2015
Montreal, Canada
Teratology Society 55th Annual Meeting

This meeting focused on the theme “Understanding Birth Defects and Reproductive Health: From Basic to Translational Research.”
Kleinstreuer presented the talk “Using ToxCast/Tox21 HTS Assays to Predict Endocrine Disruption.”
  September 22-25, 2015
Ispra, Italy
Joint Research Centre of the European Commission Adverse Outcome Pathway-informed Predictive Modelling Approaches for Regulatory Toxicology

This meeting included the foremost international experts on adverse outcome pathways (AOPs). Topics included identifying data needs for developing key AOPs for regulatory applications, how AOPs might be used for prediction of toxicity, and what requirements need to be met to apply AOPs to regulatory needs.
Kleinstreuer participated in the workshop; a manuscript summarizing workshop recommendations is in preparation.
  Oct. 1-2, 2015
Research Triangle Park, North Carolina
American Society for Cellular and Computational Toxicology Fourth Annual Meeting

The theme of the meeting was “Integrated Approaches to Testing and Assessment: Promises and Challenges of a More Flexible Approach to Toxicology Testing.”
Casey presented a keynote address on “Moving Beyond One Test: Leveraging the Whole Toolbox for Integrated Decision Strategies.” ICCVAM member Joanna Matheson, Ph.D. (U.S. Consumer Product Safety Commission) and Judy Strickland, Ph.D., senior toxicologist on the ILS NICEATM support contract, gave presentations describing the use of computational methods and data from non-animal tests to identify substances that can cause allergic contact dermatitis. NICEATM presented five posters at the meeting describing computational methods and reference databases for development of alternative testing approaches.
  October 8-9, 2015
Baltimore, Maryland
Center for Alternatives to Animal Testing at Johns Hopkins University Read-across: Current Analysis Approaches and Regulatory Applications Kleinstreuer joined other experts presenting case studies on the use of read-across for European regulatory applications and consideration of how to incorporate biologically based similarity and uncertainty in read-across predictions. A manuscript describing workshop recommendations on good read-across practices is in preparation.
  Nov. 19-20, 2015
Arlington, Virginia
Society of Toxicology FutureTox III: Bridges for Translation

The Society of Toxicology (SOT) organized the FutureTox meeting series to address the topic of transforming 21st century science into risk assessment and regulatory decision-making.
NICEATM and ICCVAM scientists presented a poster describing the ICCVAM integrated testing strategy for predicting human skin sensitization hazard, and NICEATM scientists contributed to four posters describing reference chemical identification and computational methods for endocrine disruptor testing. Speakers and moderators at the workshop will co-author a report on the workshop for publication in 2016.