U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

ICCVAM Logo

ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015
Menu
https://ntp.niehs.nih.gov/go/794024

Acronyms and Abbreviations

3Rs: Principles of replacement, reduction, or refinement of animal use for scientific research or product safety testing

ACD: Allergic contact dermatitis

ADMET CoE: Absorption, Distribution, Metabolism, Elimination, and Toxicology Center of Excellence (U.S. Department of Defense)

AOP: Adverse outcome pathway

AR: Androgen receptor

ASCCT: American Society for Cellular and Computational Toxicology

ATSDR: Agency for Toxic Substances and Disease Registry

CPSC: U.S. Consumer Product Safety Commission

CVB: Center for Veterinary Biologics (U.S. Department of Agriculture)

CYP: Cytochrome P450 enzymes

DNTP: Division of the National Toxicology Program (National Institute of Environmental Health Sciences)

DOD: U.S. Department of Defense

DOE: U.S. Department of Energy

DOI: U.S. Department of the Interior

DOT: U.S. Department of Transportation

DREAM: Dialogue for Reverse Engineering Assessments and Methods

EDQM: European Directorate for the Quality of Medicines and HealthCare

EDSP: Endocrine Disruptor Screening Program (U.S. Environmental Protection Agency)

EPA: U.S. Environmental Protection Agency

EURL ECVAM: European Union Reference Laboratory for Alternatives to Animal Testing

FDA: U.S. Food and Drug Administration

FR: Federal Register

HIST: Murine histamine sensitization test

HSDB: Hazardous Substance Data Bank (National Library of Medicine)

HTS: High throughput screening

IATA: Integrated approach to testing and assessment

ICATM: International Cooperation on Alternative Test Methods

ICCVAM: Interagency Coordinating Committee on the Validation of Alternative Methods

ICH: International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use

ILS: Integrated Laboratory Systems, Inc.

IVIVE: In vitro to in vivo extrapolation

JaCVAM: Japanese Center for the Validation of Alternative Methods

KoCVAM: Korean Center for the Validation of Alternative Methods

LD50: In traditional acute systemic toxicity tests, the dose that produces lethality in 50% of the animals tested

LLNA: Murine local lymph node assay

NC3Rs: National Centre for the 3Rs (United Kingdom)

NCI: National Cancer Institute (National Institutes of Health)

NCSU: North Carolina State University

NICEATM: National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods

NIEHS: National Institute of Environmental Health Sciences (National Institutes of Health)

NIOSH: National Institute for Occupational Safety and Health

NIH: National Institutes of Health

NLM: National Library of Medicine (National Institutes of Health)

NTP: National Toxicology Program

OECD: Organisation for Economic Co-operation and Development

OSHA: Occupational Safety and Health Administration

P&G: Procter & Gamble

PISC: PETA International Science Consortium, Ltd.

QSAR: Quantitative structure-activity relationship

REACH: Registration, Evaluation, Authorisation and Restriction of Chemicals (European Union legislation)

SACATM: Scientific Advisory Committee on Alternative Toxicological Methods

SEAZIT: Systematic Evaluation of the Application of Zebrafish in Toxicology (National Toxicology Program)

SOT: Society of Toxicology

STE: Short time exposure

Tox21: Collaborative effort among four U.S. federal government agencies to develop more efficient approaches to predict how chemicals may affect human health

ToxCast: Toxicity Forecaster (U.S. Environmental Protection Agency)

TOXNET: Toxicology Data Network (National Library of Medicine)

U.S.C.: United States Code

USDA: U.S. Department of Agriculture

USGS: U.S. Geological Survey (U.S. Department of the Interior)

XCEL: Ex Vivo Countermeasure Evolution and Licensure Program (U.S. Department of Defense)