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ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015
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https://ntp.niehs.nih.gov/go/795733

Abstracts

Browne P, Judson R, Dixon A, Kleinstreuer N, Casey W, Bergfelt DR, Green TD, Kent R, Lynn SG, Touart L, Thomas RS. 2015. Use of computational toxicology for integrated bioactivity-exposure prioritization of the EDSP chemical universe [Abstract No. 868]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 183.

Bucher JR, Tice RR, Paules RS, Casey W, Rooney AA, Thayer K, DeVito M. 2015. Assessing confidence in Tox21 [Abstract No. 1690]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 362.

Casey W. 2015. Prioritization and predictive toxicology: estrogen receptor active compounds [Abstract No. 46]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 9.

Casey W. 2015. Using reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity [Abstract No. 1606]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 345.

Casey W, Allen D, Kleinstreuer N. 2015. Using bioactivity based read-across (BaBRA) to characterize the ToxCast library [Abstract No. 1684]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 360.

Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Rinckel L, Ceger P. 2014. Performance of the Tox21 BG1Luc and ER β-lactamase estrogen receptor transactivation assays [Abstract No. 478]. Presented at FutureTox II Pathways to Prediction: In Vitro Data and In Silico Models for Predictive Toxicology; Chapel Hill, NC; 16-17 January 2014.

Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Rinckel L, Ceger P, Allen D. 2014. Performance of the BG1Luc and ER β-lactamase estrogen receptor transactivation assays in Tox21 screening [Abstract No. 128]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):132.

Ceger P, Kleinstreuer N, Allen D, Chang X, Strickland J, Zang Q, Hamm J, Philips E, Jones B, Casey W. 2015. Curation and analysis of a rodent uterotrophic database: insights on data quality and reproducibility [Abstract No. 2641]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015.

Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W. 2014. Development of a curated database of in vivo estrogenic activity [Abstract No. 474]. Presented at FutureTox II Pathways to Prediction: In Vitro Data and In Silico Models for Predictive Toxicology; Chapel Hill, NC; 16-17 January 2014.

Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W. 2014. Development of a curated database of in vivo estrogenic activity [Abstract No. 2273i]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 609.

Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W, Allen D. 2014. Development of a curated database of in vivo estrogenic activity [Abstract No. 127]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):66.

Chang X, Kleinstreuer N, Allen D, Casey W. 2015. In vitro to in vivo extrapolation: optimizing parameters for improved predictions [Abstract]. Presented at the Fourth Annual Meeting of the American Society for Cellular and Computational Toxicology; Research Triangle Park, NC; 1-2 October 2015.

Chang X, Kleinstreuer N, Allen D, Casey W. 2015. In vitro to in vivo extrapolation: optimizing parameters for improved predictions [Abstract]. Presented at FutureTox III Bridges for Translation: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making; Arlington, VA; 19-20 November 2015.

Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, DeVito M, Allen D, Casey W. 2015. Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity [Abstract No. 757]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 162.

Chang X, Kleinstreuer N, Ceger P, Hamm J, Jones B, Rinckel L, Allen D, Casey W. 2014. Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity [Abstract No. 476]. Presented at FutureTox II Pathways to Prediction: In Vitro Data and In Silico Models for Predictive Toxicology; Chapel Hill, NC; 16-17 January 2014.

Chang X, Kleinstreuer N, Ceger P, Hamm J, Jones B, Rinckel L, Casey W. 2014. Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity [Abstract No. 2250b]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 599.

Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Hamm J, Jones B, Choksi N, Rinckel L, Allen D, Casey W. 2014. Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity [Abstract No. 129]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):132.

Ferguson S, Kleinstreuer N, Lawless M, Tice R. 2014. Prioritization of the Tox21 10K library for xenobiotic metabolism and toxicity studies using in silico metabolism models [Abstract No. 2273r]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 610.

Franzosa J, Settivari RS, Ellis-Hutchings R, Kleinstreuer N, Houck K, Carney EW, Knudsen TB. 2014. RNA-Seq analysis of the functional link between vascular disruption and adverse developmental consequences [Abstract No. 1736e]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 456.

Hamm J, Allen D, Casey W, Behl M, Hinton D, Kanungo J, Kullman S, Mattingly C, Planchart A, Tal T, Weis C. 2014. Leveraging small aquarium fishes to advance understanding of environmentally influenced human disorders and diseases [Abstract No. 146]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):75.

Hamm J, Casey W, Hsu C, Huang R, Xia M, Houck K, Chang X, Allen D, Kullman S. 2014. Targeted testing of FXR Tox21 active compounds [Abstract No. 136]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):132.

Hamm J, Kleinstreuer N, Casey W, Allen D, Padilla S. 2014. Use of the zebrafish developmental screen and estimation of internal concentration to assess toxicity [Abstract No. 144]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):75.

Hamm J, Kleinstreuer N, Padilla S, Casey W. 2014. Use of the zebrafish developmental screen and estimation of internal concentration to assess toxicity [Abstract No. 440h]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 114.

Heinonen T, Toimela T, Knudsen TB, Kleinstreuer N, Sarkanen R. 2014. Evaluation of environmental chemicals computationally predicted to disrupt angiogenesis [Abstract No. 1087o]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 286.

Hsu C, Zhao J, Huang R, Houck K, Hsieh J, Hamm J, Chang X, Xia M. 2014. Quantitative profiling of environmental chemicals and drugs for farnesoid X receptor activity [Abstract No. 1149]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 305.

Huang R, Sakamuru S, Martin MT, Reif D, Judson R, Houck K, Casey W, Hsieh J-H, Shockley K, Ceger P, Fostel J, Witt KL, Tong W, Rotroff D, Simeonov A, Dix DJ, Austin CP, Kavlock R, Tice, R, Xia M. 2014. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway [Abstract No. 173b]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 41.

Kleinstreuer N. 2015. Combining data streams and modeling approaches to develop skin sensitization ITS. Presented at OpenTox USA 2015; Baltimore, MD; 10-12 February 2015.

Kleinstreuer N, Allen D, Ceger P, Chang X, Strickland J, Zang Q, Hamm J, Jones B, Casey W. 2014. Using in vitro HTS methods to identify endocrine disruptors [Abstract No. 133]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):81.

Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W. 2015. Identifying reference chemicals for androgen receptor activity [Abstract]. Presented at the Fourth Annual Meeting of the American Society for Cellular and Computational Toxicology; Research Triangle Park, NC; 1-2 October 2015.

Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W. 2015. Identifying reference chemicals for androgen receptor activity [Abstract]. Presented at FutureTox III Bridges for Translation: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making; Arlington, VA; 19-20 November 2015.

Kleinstreuer N, Filer D, Martin M, Houck K, Zang Q, Allen D, Casey W, Judson R. 2014. Integrating ToxCast assays into an androgen receptor (AR) pathway model [Abstract No. 67]. Presented at the Second ToxCast Data Summit; Research Triangle Park, NC; 29-30 September 2014.

Kleinstreuer N, Strickland J, Allen D, Casey W. 2014. Predicting skin sensitization using ToxCast assays [Abstract No. 68]. Presented at the Second ToxCast Data Summit; Research Triangle Park, NC; 29-30 September 2014.

Kleinstreuer N, Strickland J, Casey W. 2014. Predicting skin sensitization using 21st century toxicology [Abstract No. 475]. Presented at FutureTox II Pathways to Prediction: In Vitro Data and In Silico Models for Predictive Toxicology; Chapel Hill, NC; 16-17 January 2014.

Kleinstreuer N, Strickland J, Casey W. 2014. Predicting skin sensitization using 21st century toxicology [Abstract No. 1062c]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 276.

Kleinstreuer N, Strickland J, Casey W. 2014. Predicting skin sensitization using 21st century toxicology [Abstract No. 132]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):120.

Kleinstreuer N, Tal TL, Knudsen TB, Heinonen T, Franzosa J, Baker N, Padilla S, Carney E, Casey W. 2014. Constructing, quantifying, and validating an outcome pathway for vascular developmental toxicity [Abstract No. 376]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):55.

Kleinstreuer N, Zang Q, Filer D, Martin M, Houck K, Allen D, Casey W, Judson R. 2015. Using ToxCast/Tox21 assays and QSAR modeling to predict androgen receptor pathway activity [Abstract No. 1335]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22–26 March 2015. Toxicol Sci/Toxicologist 144(1): 285-286.

Mansouri K, Politi R, Farag S, Muratov E, Tropsha A, Judson R, Zang Q, Allen D, Casey W, Kleinstreuer N. 2015. Domain-specific QSAR model for identifying potential estrogenic activity [Abstract]. Presented at the Fourth Annual Meeting of the American Society for Cellular and Computational Toxicology; Research Triangle Park, NC; 1-2 October 2015.

Mansouri K, Politi R, Farag S, Muratov E, Tropsha A, Judson R, Zang Q, Allen D, Casey W, Kleinstreuer N. 2015. QSAR models for identifying potential estrogenic activity of phenolic compounds [Abstract]. Presented at FutureTox III Bridges for Translation: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making; Arlington, VA; 19-20 November 2015.

Matheson J, Zang Q, Strickland J, Kleinstreuer N, Allen D, Lowit A, Jacobs A, Casey W. 2015. ICCVAM integrated decision strategy for skin sensitization [Abstract No. 421]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 90.

Paris M, Strickland J, Allen D, Casey W. 2015. Using acute oral toxicity data to estimate acute dermal hazard classification and labeling of pesticides [Abstract No. 1911]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 410.

Pirone J, Smith M, Kleinstreuer N, Burns T, Strickland J, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J. 2014. Development of an open-source integrated test strategy for skin sensitization potency [Abstract No. 1831l]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 482.

Pirone J, Smith M, Kleinstreuer N, Burns T, Strickland J, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J. 2014. Development of an open-source integrated test strategy for skin sensitization potency [Abstract No. 134]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):121.

Pirone J, Smith M, Strickland J, Casey W, Jaworska J. 2015. Impact of local lymph node assay uncertainty on predictions of a Bayesian network integrated testing strategy for skin sensitization potency [Abstract No. 1315]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 281.

Pirone J, Strickland J, Smith M, Kleinstreuer N, Jones B, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J. 2014. Development of an open-source integrated test strategy for skin sensitization potency [Abstract No. 480]. Presented at FutureTox II Pathways to Prediction: In Vitro Data and In Silico Models for Predictive Toxicology; Chapel Hill, NC; 16-17 January 2014.

Polk W, Kleinstreuer N, Strickland J, Paris M, Allen D, Casey W. 2015. Correlation of Tox21 and ToxCast in vitro and small model organism outcomes to rat oral toxicity [Abstract No. 1179]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 251.

Rattner BA.  2015. Alternative methods and study design refinements to reduce or replace animal use in wildlife toxicity tests [Abstract WE035]. Presented at the Society of Environmental Toxicology and Chemistry-Europe 25th Annual Meeting; Barcelona, Spain; 3-7 May 2015.

Riegerix, R, Tillitt DE. 2015. Toxicity of anticoagulant rodenticides in two freshwater fishes to aid test design for Hawaiian triggerfish [Abstract WP206].  Presented at the Society of Environmental Toxicology and Chemistry-North America 26th Annual Meeting; Salt Lake City, Utah; 1-5 November 2015.

Rinckel L, Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Ceger P. 2014. Performance of the Tox21 BG1Luc and ER β-lactamase estrogen receptor transactivation assays in Tox21 [Abstract No. 173h]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 43.

Strickland J, Choksi N, Allen D, Casey W. 2015. In silico predictions of skin sensitization using OECD QSAR Toolbox [Abstract No. 422]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 90.

Strickland J, Zang Q, Paris M, Kleinstreuer N, Lehmann DM, Allen D, Matheson J, Jacobs A, Lowit A, Casey W. 2015. Machine learning approaches for predicting human skin sensitization hazard [Abstract]. Presented at the Fourth Annual Meeting of the American Society for Cellular and Computational Toxicology; Research Triangle Park, NC; 1-2 October 2015.

Strickland J, Zang Q, Paris M, Kleinstreuer N, Lehmann DM, Allen D, Matheson J, Jacobs A, Lowit A, Casey W. 2015. Machine learning approaches for predicting human skin sensitization hazard [Abstract]. Presented at FutureTox III Bridges for Translation: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making; Arlington, VA; 19-20 November 2015.

Tal TL, Kleinstreuer N, Harris P, Olin J, Palekar A, Toimela T, Sarkanen R, Heinonen T, Knudsen TB, Padilla S. 2014. Adverse outcome pathway for embryonic vascular disruption and alternative methods to identify chemical vascular disruptors during development [Abstract No. 1062a]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 275.

Tropsha A, Alves V, Muratov E, Fourches E, Strickland J, Kleinstreuer N, Andrade C. 2014. Identification of putative skin sensitizers using QSAR models enriched by in vitro data [Abstract No. 2182c]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 571.

Wang A, Franzosa J, Shah I, Filer DL, Kleinstreuer N, Marinakos S, Houck K. 2014. Comparing bioactivity profiles of diverse nanomaterials based on high-throughput screening (HTS) in ToxCast™ [Abstract No. 1973e]. Presented at the 53rd Annual Meeting of the Society of Toxicology; Phoenix, AZ; 23-27 March 2014. Toxicol Sci/Toxicologist 138(1): 520.

Wetmore B, Casey W. 2015. Incorporating in vitro pharmacokinetic data and tools into toxicity testing and risk assessment: state of the science [Abstract No. 1603]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 345.

Zang Q, Kleinstreuer N, Allen D, Casey W, Judson R. 2015. QSAR modeling for the prediction of androgen receptor pathway activity [Abstract]. Presented at the Fourth Annual Meeting of the American Society for Cellular and Computational Toxicology; Research Triangle Park, NC; 1-2 October 2015.

Zang Q, Kleinstreuer N, Allen D, Casey W, Judson R. 2015. QSAR modeling to predict androgen receptor pathway activity [Abstract]. Presented at FutureTox III Bridges for Translation: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making; Arlington, VA; 19-20 November 2015.

Zang Q, Mansouri K, Allen D, Casey W, Judson R. 2014. Prediction of physicochemical properties of environmental chemicals using molecular fingerprints and machine learning methods [Abstract No. 131]. Presented at the Ninth World Congress on Alternatives and Animal Use in the Life Sciences; Prague, Czech Republic; 24-28 August 2014. ALTEX Proceedings 3(1):67.

Zang Q, Mansouri K, Allen D, Kleinstreuer N, Casey W, Judson R. In silico prediction of physicochemical properties of environmental chemicals in combination of molecular fingerprints and machine learning approaches [Abstract No. 2237]. Presented at the 54th Annual Meeting of the Society of Toxicology; San Diego, CA; 22-26 March 2015. Toxicol Sci/Toxicologist 144(1): 480.