ICCVAM Biennial Report 2014-2015

ICCVAM Biennial Report 2014-2015


Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A. 2015. Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicol Appl Pharmacol 284(2):262-272.

Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A. 2015. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization. Toxicol Appl Pharmacol 284(2):273-280.

Browne P, Judson R, Casey W, Kleinstreuer N, Thomas R. 2015. Screening chemicals for estrogen receptor bioactivity using a computational model. Environ Sci Technol 49(14):8804-8814.

Casey W, Jacobs A, Maull E, Matheson J, Clarke C, Lowit A. 2015. A new path forward: the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). J Am Assoc Lab Anim Sci 54(2): 170-173.

Ceger P, Allen D, Huang R, Xia M, Casey W. 2015. Performance of the BG1Luc ER TA method in a qHTS format. ALTEX 32(4):287-296.
Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Allen D, Casey W. 2015. Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity. Appl In Vitro Toxicol 1(1): 33-44.

Goodson WH, Lowe L, Carpenter DO, (107 other authors), Kleinstreuer N, (60 other authors), Luqmani Y, Chen Z, Hu Z. 2015. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36(Suppl 1):S254-S296.

Hsu CW, Zhao J, Huang R, Hsieh J-H, Hamm J, Chang X, Houck K, M Xia. 2014. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep http://dx.doi.org/10.1038/srep06437.

Hu Z, Brooks SA, Dormoy V, (24 other authors), Lowe L, Jensen L, Bisson WH, Kleinstreuer N. 2015. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Carcinogenesis 36(Suppl 1):S184-S202.

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh J-H, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M. 2014. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Sci Rep http://dx.doi.org/10.1038/srep05664.

Isbrucker R, Arciniega J, McFarland R, Chapsal J-M, Xing D, Bache C, Nelson S, Costanzo A, Hoonakker M, Castiaux A, Halder M, Casey W, Johnson N, Jones B, Doelling V, Sprankle C, Rinckel L, Stokes W. 2014. Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward. Biologicals 42(2):114-122.

Jaworska JS, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M. 2015. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy. Arch Toxicol 89:2355-2383.

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG, Willett CE, Andersen ME, Borgert CJ, Coady KK, Dourson ML, Fowle JR, Gray LE, Lamb JC, Ortego LS, Schug TT, Toole CM, Zorrilla LM, Kroner OL, Patterson J, Rinckel LA, Jones BR. 2014. t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 31:63-78.

Kleinstreuer NC, Ceger PC, Allen DG, Strickland J, Chang X, Hamm JT, Casey WM. 2015. A curated database of rodent uterotrophic bioactivity. Environ Health Perspect http://dx.doi.org/10.1289/ehp.1510183.

Kleinstreuer N, Yang J, Berg EL, Knudsen TB, Richard AM, Martin MT, Reif DM, Judson RS, Polokoff M, Dix DJ, Kavlock RJ, Houck KA. 2014. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms. Nat Biotechnol 32:583-591.
Winner, 2015 Best Publication Award, Society of Toxicology Biotechnology Specialty Section

McKim J, Bahadori T, Casey W, Paules R, Thomas R. 2015. Changing the paradigm of toxicity testing from observational to predictive: an update on two global screening initiatives. Appl In Vitro Toxicol 1(2):91-98.

McKim A, Goldberg A, Kleinstreuer N, Busquet F, Andersen M. 2014. Roundtable discussion: comments on how to make the new vision of toxicity testing in the 21st century a reality. Appl In Vitro Toxicol 1(1): 5-10.

Pirone JR, Smith M, Kleinstreuer NC, Burns TA, Strickland J, Dancik Y, Morris R, Rinckel LA, Casey W, Jaworska JA. 2014. Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network. ALTEX 31(3): 336-340.

Rovida C, Alepee N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Sch├╝├╝rmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. 2015. Integrated testing strategies (ITS) for safety assessment. ALTEX 32(1):25-40.

Rattner BA, Lazarus RS, Elliott JE, Shore RF, van den Brink N. 2014. Adverse outcome pathway and risks of anticoagulant rodenticides to predatory wildlife. Environ Sci Technol 48(15):8433-8440.

Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TB, Padilla S, Hemmer MJ. 2014. Immediate and long-term consequences of vascular toxicity during zebrafish development. Reprod Toxicol 48:51-61.