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ICCVAM Biennial Report 2016-2017

Biennial Progress Report 2016-2017 Interagency Coordinating Committee on the Validation of Alternative Methods

A Message from NICEATM and ICCVAM

On behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), we are pleased to present the 2016-2017 ICCVAM Biennial Progress Report. This report describes activities of ICCVAM and its 16 member agencies that support the ICCVAM mission of facilitating development, validation, and regulatory acceptance of new testing approaches.

A major activity for ICCVAM during this period was development and publication of the Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. This document, released in January 2018, reflects the contributions of dozens of representatives of ICCVAM member agencies as well as input from ICCVAM stakeholders. We envision that the Strategic Roadmap will expedite the development and use of new approach methodologies that provide information more relevant to human health than existing animal-based methods.

In addition to describing development of the Strategic Roadmap, this Biennial Report summarizes a broad range of activities undertaken during 2016 and 2017 by ICCVAM member agencies to advance alternatives to animal use for chemical safety testing. Some of these activities focus on reducing animal use, such as guidances issued by EPA and USDA that allow waiving of required animal tests under specific circumstances. Other activities have the potential to replace animal use, such as implementation of non-animal approaches developed by ICCVAM agency scientists to identify potential skin sensitizers and endocrine disruptors.

ICCVAM continues to work with NICEATM on outreach efforts. These activities raise awareness of available alternative methods and foster partnerships with stakeholders to maximize efficiency of development, validation, and implementation of new methods. During 2016 and 2017, ICCVAM convened two Public Forum meetings and participated in two public meetings of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM). The Public Forums were each viewed by dozens of webcast viewers and generated productive interactions between ICCVAM representatives and stakeholders. These meetings provided opportunities for ICCVAM agency representatives to present updates on activities, which enabled the SACATM meetings to focus on substantive strategic and technical discussions to better leverage the expertise of the SACATM members in advancing the ICCVAM mission. NICEATM and ICCVAM also presented webinar series on alternative approaches for inhalation toxicity and improving data analysis for chemical screening assays conducted in zebrafish, as well as two ICCVAM Communities of Practice webinars on current topics in cheminformatics.

For the first time since ICCVAM was established, ICCVAM added a new member agency to the committee. In March 2016, the National Institute of Standards and Technology (NIST) became the 16th ICCVAM member agency, bringing expertise and interest in measurement science and method validation to ICCVAM’s activities. The Biennial Report describes several NIST activities, undertaken both independently and in collaboration with other ICCVAM agencies.

We gratefully acknowledge the contributions of the representatives and interagency working group members from the 16 ICCVAM member agencies, particularly those who applied their insight and expertise to development of the Strategic Roadmap. Special thanks and recognition are due to Abigail Jacobs, Ph.D., who retired from the U.S. Food and Drug Administration in 2017 after many years of service to ICCVAM, including nearly five years serving as the Committee’s co-chair. We also acknowledge the contributions from NICEATM and its contract staff, the members of SACATM, and our many other stakeholders.

The activities summarized in this report exemplify ICCVAM’s ongoing commitment to working with U.S. and international partners to advance the development and acceptance of new scientifically valid test methods that will reduce and eventually replace animal use. We look forward to continued progress and effective interactions with our stakeholders in the coming years.

Anna Lowit, Ph.D.
Co-Chair, ICCVAM
Office of Pesticide Programs within the
Office of Chemical Safety and Pollution Prevention
U.S. Environmental Protection Agency

Emily Reinke, Ph.D., D.A.B.T.
Co-Chair, ICCVAM
Toxicology Directorate
U.S. Army Public Health Center

Warren Casey, Ph.D., D.A.B.T.
Director, NICEATM
Administrative Director, ICCVAM
National Institute of Environmental Health Sciences

ICCVAM Co-chair Anna Lowit, Ph.D.

ICCVAM Co-chair Anna Lowit, Ph.D.

ICCVAM Co-chair Emily Reinke

ICCVAM Co-chair Emily Reinke, Ph.D.

NICEATM Director Warren Casey, Ph.D.

NICEATM Director Warren Casey, Ph.D.