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ICCVAM Biennial Report 2016-2017

ICCVAM Biennial Report 2016-2017
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https://ntp.niehs.nih.gov/go/843106

ICCVAM Communities of Practice Webinars

ICCVAM initiated a series of Communities of Practice webinars in 2015 to provide opportunities for detailed consideration of a current topic relevant to alternative test method development.

  • The second of these webinars, presented on Jan. 26, 2016, was titled Fundamentals of Using Quantitative Structure-Activity Relationship Models and Read-across Techniques in Predictive Toxicology. The webinar, which was viewed by over 250 people, focused on applications of methods that use chemical structure, properties, and toxicity data to predict characteristics of untested chemicals. Alex Tropsha, Ph.D., University of North Carolina at Chapel Hill, provided an overview of how quantitative structure-activity relationship models are used in this context. Louis (Gino) Scarano, Ph.D., of the EPA Office of Pollution Prevention and Toxics, reviewed how the EPA uses quantitative tools and models to generate predictions of toxic effects of new chemicals, which can then be used to make occupational risk assessments and identify where further testing might be needed.
  • Nearly 200 viewers attended the Jan. 24, 2017, Communities of Practice webinar, which emphasized the importance of understanding the structural and functional diversity of chemical sets used in developing and validating alternative approaches to traditional in vivo toxicology test methods. Presentations by Denis Fourches, Ph.D., of North Carolina State University, and Kamel Mansouri, Ph.D., of the EPA National Center for Computational Toxicology, featured next-generation chemoinformatics techniques that are being used to fully characterize chemical lists, as well as case studies where such techniques have been successfully applied.