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ICCVAM Biennial Report 2016-2017

ICCVAM Biennial Report 2016-2017

ICCVAM Contributions to OECD Activities

ICCVAM member agencies participate in the development and national review of guidelines for the testing of chemicals issued by the Test Guidelines Programme of the Organisation for Economic Co-operation and Development (OECD). OECD test guidelines represent internationally agreed upon testing methods that can be used by government, industry, and independent laboratories in the 35 OECD member countries to determine the safety of chemicals and chemical preparations.

The U.S. National Coordinator for the OECD Test Guidelines Programme, an ex officio member of ICCVAM, solicits and collates U.S. comments on draft test guidelines and other documents of the Test Guidelines Programme. The National Coordinator represents the United States at the annual meeting of the Working Group of National Coordinators and in other test guideline development activities. Wanda Hall, EPA, has served as U.S. National Coordinator since 2015.

In addition to reviewing a number of test guidelines under revision during 2016 and 2017, NICEATM and ICCVAM collaborated with international colleagues on a revision of the acute dermal toxicity test guideline (Test Guideline 402) adopted by OECD in 2017. NICEATM and ICCVAM also collaborated with international colleagues on the following OECD activities:

  • Drafting of a new proposal for a performance-based test guideline regarding defined approaches and test methods for skin sensitization submitted to OECD in fiscal year 2017 (work product of the 2016 ICATM Skin Sensitization Workshop)
  • Drafting of a guidance document on integrated approaches to testing and assessment (IATAs) for eye irritation hazard potential
  • Drafting of a guidance document on the reporting of defined approaches to be used within IATAs
  • Contributing a case study to a guidance document on reporting defined approaches and individual information sources for skin sensitization
NICEATM staff members participated in the following OECD activities during 2016 and 2017:
  • A peer review panel updating Test Guideline 442B for non-radiolabeled murine local lymph node assay methods.
  • Expert meetings on skin sensitization and skin and eye irritation in November 2016 and November 2017. Participants at these meetings review and comment on draft test guidelines. Revisions based on the expert groups’ recommendations are circulated to the OECD member countries and are ultimately considered for approval and formal adoption by the OECD Working Group of National Coordinators.
  • Meetings in November 2016 and October 2017 of the OECD Validation Management Group-Non-animal. This international group focuses on evaluation of new methods for identifying endocrine disruptors.
  • A special session of the OECD Working Group of National Coordinators in December 2017 to discuss the proposal for a new performance-based test guideline for defined approaches to skin sensitization testing and assessment.