ICCVAM Biennial Report 2016-2017

Participants in the workshop (1) reviewed the state of the science to form recommendations on the best practices for using in vitro to in vivo extrapolation in chemical screening and risk decision making, (2) identified areas that require additional data and/or research, and (3) highlighted examples of how best to apply IVIVE in a tiered risk decision-making strategy.

Meeting Location: RTP, North Carolina
Meeting Link: In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making

The webinar series explored and discussed alternative approaches that could replace, reduce, or refine the use of animals for identifying chemicals that may cause acute systemic toxicity when inhaled. The subsequent workshop developed recommendations for advancing new approaches for acute inhalation toxicity testing.

Meeting Location: Online/Bethesda, Maryland
Meeting Link: Alternative Approaches for Acute Inhalation Toxicity Testing

This workshop for scientists involved in assay development for HTS and lead optimization shared best practices and provided advice on robust assay design.

Meeting Location: College Park, Maryland

Attendees at this symposium learned how scientists are using software licensed by the NIH Library Bioinformatics Support Program to analyze, integrate, and annotate data from multiple genomics technologies.

Meeting Location: Bethesda, Maryland

This workshop featured presentations by Stage 1 winners of the Transform Tox Testing Challenge and provided opportunities to discuss the remainder of the challenge.

Meeting Location: RTP, North Carolina
Meeting Link: Transform Tox Testing Challenge Workshop

The FDA held this webinar for industry to review the recommendations in this final guidance and to clarify and update how medical device developers may use ISO 10993-1 standard in their premarket submission to determine the potential for an unacceptable adverse biological response resulting from contact of a medical device with the body.

Meeting Location: Online
Meeting Link: Final Guidance on "Use of International Standard ISO 10993-1, Biological evaluation of medical devices – Part 1: Evaluation and testing within a risk management process"

This webinar, intended for interested investigators, provided an overview of a program to use organ-on-chip platforms to better understand the molecular and cellular basis of human disease in microgravity.

Meeting Location: Online

This overview of current topics in computational biology featured two discussion panels on near-term challenges and opportunities in the field and how computational biology and computing in general will affect human health.

Meeting Location: Bethesda, Maryland
Meeting Link: Computational Biology: Past, Present, and Future

This webinar described and demonstrated the use of ALTBIB, NLM's online resource for alternatives to vertebrate animal use in research and testing.

Meeting Location: Online

This webinar series considered how issues of variability in zebrafish toxicological screening studies might be addressed by use of standardized nomenclature systems, also known as ontologies.

Meeting Location: Online
Meeting Link: Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish

This workshop brought representatives from international projects investigating adverse outcome pathways, with the goal of developing recommendations toward fully implementing a human systems-biology platform for understanding disease and improving interventions.

Meeting Location: Bethesda, Maryland
Meeting Link: BioMed21: A Human Pathways Approach to Disease Research

The FDA hosted this webinar for tool developers and stakeholders interested in learning more about the guidance document and the Medical Device Development Tools program.

Meeting Location: Online
Meeting Link: CDRH Final Guidance: Qualification of Medical Device Development Tools

This webinar series featured four government and academic research groups describing their approaches to genomic dose-response modeling, which uses toxicogenomics data for risk assessment applications.

Meeting Location: Online
Meeting Link: Approaches to Genomic Dose-Response Modeling

The latest in the series Colloquia on Emerging Toxicological Science: Challenges in Food and Ingredient Safety featured expert reviews on state-of-the-art in vitro technologies for safety assessment and how they are being utilized.

Meeting Location: College Park, Maryland
Meeting Link: In Vitro to In Vivo Concordance for Toxicity Prediction and Use in Safety Assessments

The webinar series examined how the adverse outcome pathway framework can help support greater use of mechanistic or pathway-based data in risk assessment and regulatory decision making.

Meeting Location: Online
Meeting Link: Superfund Research Program Risk e-Learning Seminars on Adverse Outcome Pathways

EPA is developing a strategic plan to promote the development and implementation of alternative test methods and strategies to reduce, refine, or replace vertebrate animal testing. This meeting provided an opportunity for public comment on the plan.

Meeting Location: Bethesda, Maryland
Meeting Link: Alternative Test Methods to Reduce Vertebrate Animal Testing under the Toxic Substances Control Act

This webinar provided an overview of programs and funding that support small businesses and technology transfer organizations, including those involved in the development of alternative testing approaches.

Meeting Location: Online

This meeting of the Federal Insecticide, Fungicide, and Rodenticide Scientific Advisory Panel considered the use of high-throughput assays and computational models in the EPA Endocrine Disruptor Screening Program.

Meeting Location: Arlington, Virginia
Meeting Link: Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, Focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways