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ICCVAM Biennial Report 2016-2017

ICCVAM Biennial Report 2016-2017
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NICEATM and ICCVAM Publications, 2016-2017

NICEATM and ICCVAM Reports

ICCVAM. 2016. Biennial progress report 2014-2015: Interagency Coordinating Committee on the Validation of Alternative Methods [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences.

Federal Register Notices

All Federal Register notices issued by NICEATM can be found on the NTP website.

NIEHS. 2016. Interagency Coordinating Committee on the Validation of Alternative Methods; notice of public meeting; request for public input. Federal Register. 81(53):14865-14866.

NIEHS. 2016. Alternative approaches for acute inhalation toxicity to address global regulatory and non-regulatory data requirements; notice of webinars; registration information. Federal Register. 81(53):14864-14865.

NIEHS. 2016. Request for data and information on technologies used for identifying potential developmental toxicants. Federal Register. 81(126):42718-42719.

NIEHS. 2016. Request for data and information on technologies used to identify substances with the potential to cause acute systemic toxicity. Federal Register. 81(137):46696.

NIEHS. 2016. Scientific Advisory Committee on Alternative Toxicological Methods; announcement of meeting; request for comments. Federal Register. 81(161):55468-55469.

NIEHS. 2016. ICCVAM biennial progress report: 2014-2015; availability of report. Federal Register. 81(164):57926-57927.

NIEHS. 2016. Request for data and information on zebrafish embryo chemical screening. Federal Register. 81(213):76620-76621.

NIEHS. 2016. Using informatics to improve data analysis of chemical screening assays conducted in zebrafish; notice of webinars; registration information. Federal Register. 81(250):96024-96025.

NIEHS. 2016. Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice webinar on incorporating chemical information: resources, limitations, and characterizing the domain of applicability for 21st century toxicity testing; notice of public webinar; registration information. Federal Register. 81(250):96025-96026.

NIEHS. 2017. ICCVAM notice of public meeting; request for public input. Federal Register. 82(78):19071-19073.

NIEHS. 2017. Scientific Advisory Committee on Alternative Toxicological Methods; announcement of meeting; request for comments. Federal Register. 82(168)161:37885-37887.

Journal Articles

Alves V, Capuzzi S, Muratov E, Braga R, Thornton T, Fourches D, Strickland J, Kleinstreuer N, Andrade C, Tropsha A. 2016. QSAR models of human data can enrich or replace LLNA testing for human skin sensitization. Green Chem. 18(24):6501-6515. https://doi.org/10.1039/C6GC01836J

Arciniega J, Wagner L, Prymula R, Sebo P, Isbrucker R, Descampe B, Chapsal JM, Costanzo A, Hendriksen C, Hoonaker M, Nelson S, Lidster K, Casey W, Allen D. 2016. Alternatives to HIST for acellular pertussis vaccines: progress and challenges in replacement. Report on an international workshop. Pharmeur Bio Sci Notes. 82-96.

Ball N, Cronin MTD, Shen J, Adenuga MD, Blackburn K, Booth ED, Bouhifd M, Donley E, Egnash L, Freeman JJ, Hastings C, Juberg DR, Kleensang A, Kleinstreuer N, Kroese ED, Lee AC, Luechtefeld T, Maertens A, Marty S, Naciff JM, Palmer J, Pamies D, Penman M, Richarz A-N, Russo DP, Stuard SB, Patlewicz G, van Ravenzwaay B, Wu S, Zhu H, Hartung T. 2016. Toward good read-across practice (GRAP) guidance. ALTEX. 33(2):149-166. https://doi.org/10.14573/altex.1601251

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol In Vitro. 47:213-227. https://doi.org/10.1016/j.tiv.2017.11.016

Bell SM, Phillips J, Sedykh A, Tandon A, Sprankle C, Morefield SQ, Shapiro A, Allen D, Shah R, Maull EA, Casey WM, Kleinstreuer NC. 2017. An integrated chemical environment to support 21st century toxicology. Environ Health Perspect. 125(5):054501. https://doi.org/10.1289/EHP1759

Braga R, Alves V, Muratov E, Strickland J, Kleinstreuer N, Tropsha A, Andrade C. 2017. Pred-Skin: a fast and reliable web app to assess skin sensitization effect of chemicals. J Chem Inf Model. 57(5):1013-1017. https://doi.org/10.1021/acs.jcim.7b00194

Browne P, Noyes PD, Casey WM, Dix DJ. 2017. Application of adverse outcome pathways to U.S. EPA's Endocrine Disruptor Screening Program. Environ Health Perspect. 125(9):096001. https://doi.org/10.1289/EHP1304

Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Regimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V. 2017. Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol. 92(2):611-617. https://doi.org/10.1007/s00204-017-2097-4

Casey WM. 2016. Advances in the development and validation of test methods in the United States. Toxicol Res. 32:9-14. https://doi.org/10.5487/TR.2016.32.1.009

Clippinger AJ, Ahluwalia A, Allen D, Bonner JC, Casey W, Castranova V, David RM, Halappnavar S, Hotchkiss JA, Jarabek AM, Maier M, Polk W, Rothen-Rutishauser B, Sayes CM, Sayre P, Sharma M, Stone V. 2016. Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials. Arch Toxicol. 90(7):1769-1783. https://doi.org/10.1007/s00204-016-1717-8

Elliott JT, Rosslein M, Song NW, Toman B, Kinsner-Ovaskainen A, Maniratanachote R, Salit ML, Petersen EJ, Sequeira F, Lee J, Kim SJ, Rossi F, Hirsch C, Krug H F, Suchaoin W, Wick P. 2017. Toward achieving harmonization in a nano-cytotoxicity assay measurement through an interlaboratory comparison study. ALTEX. 34(2):201-218. https://doi.org/10.14573/altex.1605021

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW. 2017. Embryonic vascular disruption adverse outcomes: linking high-throughput signaling signatures with functional consequences. Reprod Toxicol. 70:82-96. https://doi.org/10.1016/j.reprotox.2017.05.005

El-Masri H, Kleinstreuer N, Hines RN, Adams L, Tal T, Isaacs K, Wetmore B, Tan Y-M. 2016. Integration of life-stage physiologically based pharmacokinetic (PBPK) models with adverse outcome pathways (AOPs) and environmental exposure models to screen for environmental hazards. Toxicol Sci. 152(1):230-243. https://doi.org/10.1093/toxsci/kfw082

Grego S, Dougherty DR, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MN, Martin F, Maull EA, Paragas F, Qiao G, Ramaiahgari S, Sumner SJ, Yoon M. 2017. Systems biology for organotypic cell cultures. ALTEX. 34(2):301-310. https://doi.org/10.14573/altex.1608221

Griesinger C, Desprez B, Coecke S, Casey W, Zuang V. 2016. Validation of alternative in vitro methods to animal testing: concepts, challenges, processes and tools. Adv Exp Med Biol. 856:65-132. https://doi.org/10.1007/978-3-319-33826-2_4

Hamm J, Sullivan K, Clippinger AJ, Strickland J, Bell S, Bhhatarai B, Blaauboer B, Casey W, Dorman D, Forsby A, Garcia-Reyero N, Gehen S, Graepel R, Hotchkiss J, Lowit A, Matheson J, Reaves E, Scarano L, Sprankle C, Tunkel J, Wilson D, Xia M, Zhu H, Allen D. 2017. Alternative approaches for identifying acute systemic toxicity: moving from research to regulatory testing. Toxicol In Vitro. 41:245-259. https://doi.org/10.1016/j.tiv.2017.01.004

Hanna SK, Cooksey GA, Dong S, Nelson BC, Mao L, Elliott JT, Petersen EJ. 2016. Feasibility of using a standardized Caenorhabditis elegans toxicity test to assess nanomaterial toxicity. Environ Sci: Nano. 3:1080-1089. http://dx.doi.org/10.1039/C6EN00105J

Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Setzer RW, Kothiya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS. 2016. Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. Toxicol Sci. 152(2):323-339. https://doi.org/10.1093/toxsci/kfw092

Kleinstreuer NC, Ceger P, Allen DG, Strickland J, Chang X, Hamm JT, Casey WM. 2016. A curated database of rodent uterotrophic bioactivity. Environ Health Perspect. 124(5):556-562. https://doi.org/10.1289/ehp
Link to Web page with database

Kleinstreuer NC, Ceger P, Watt ED, Martin MT, Houck KA, Browne P, Thomas RS, Casey W, Dix D, Allen D, Sakamuru S, Xia M, Huang R, Judson RS. 2017. Development and validation of a computational model for androgen receptor activity. Chem Res Toxicol. 30(4):946-964. https://doi.org/10.1021/acs.chemrestox.6b00347

Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. 2016. Adverse Outcome Pathways: From Research to Regulation scientific workshop report. Reg Toxicol Pharmacol. 76:39-50. https://doi.org/10.1016/j.yrtph.2016.01.007

Lillicrap A, Belanger S, Burden N, Pasquier DD, Embry MR, Halder M, Lampi MA, Lee L, Norberg-King T, Rattner BA, Schirmer K, Thomas P. 2016. Alternative approaches to vertebrate ecotoxicity tests in the 21st century: a review of developments over the last two decades and current status. Environ Toxicol Chem. 35:2637-2646. https://doi.org/10.1002/etc.3603

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M. 2017. Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology. 385:48-58. https://doi.org/10.1016/j.tox.2017.05.001

Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS. 2016. CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. Environ Health Perspect. 124(7):1023-1033. https://doi.org/10.1289/ehp.1510267

Martin LA, Porter AG, Pelligrini VA, Schnatz PA, Jiang X, Kleinstreuer N, Hall JE, Verbiest S, Olmstead J, Fair R, Falorni A, Persani L, Rajkovic A, Mehta K, Nelson LM. 2017. A design thinking approach to primary ovarian insufficiency. Panminerva Med. 59(1):15-32. https://doi.org/10.23736/S0031-0808.16.03259-6

McCollum CW, de Vancells JC, Hans C, Vazquez-Chantada M, Kleinstreuer NC, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson J, Cabrera R, Bondesson M. 2017. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. Reprod Toxicol. 70:60-69. https://doi.org/10.1016/j.reprotox.2016.11.005

Mielke H, Strickland J, Jacobs MN, Mehta JM. 2017. Biometrical evaluation of the performance of the revised OECD Test Guideline 402 for assessing acute dermal toxicity. Regul Toxicol Pharmacol. 89:26-39. https://doi.org/10.1016/j.yrtph.2017.07.007

Miller MF, Goodson WH, Manjili MH, Kleinstreuer N, Bisson WH, Lowe L. 2017. Low-dose mixture hypothesis of carcinogenesis workshop: scientific underpinnings and research recommendations. Environ Health Perspect. 125(2):163-169. https://doi.org/10.1289/EHP411

Oki N, Leonard J, Nelms M, Bell S, Tan Y-M, Burgoon L, Edwards S. 2017. Linking environmental exposure to toxicity. In: Richardson RJ, Johnson DE, eds. Computational systems pharmacology and toxicology. Cambridge (UK): Royal Society of Chemistry. p. 60-88. https://doi.org/10.1039/9781782623731

Oki NO, Nelms MD, Bell SM, Mortensen HM, Edwards SW. 2016. Accelerating adverse outcome pathway development using publicly available data sources. Curr Environ Health Rep. 3(1):53-63. https://doi.org/10.1007/s40572-016-0079-y

Pamies D, Bal-Price A, Simeonov A, Tagle D, Allen D, Gerhold D, Yin D, Pistollato F, Inutsuka T, Sullivan K, Stacey G, Salem H, Leist M, Daneshian M, Vermuri MC, McFarland R, Coecke S, Fitzpatrick SC, Lakshmipathy U, Mack A, Wang WB, Daiju Y, Sekino Y, Kanda Y, Smirnova L, Hartung T. 2017. Good cell culture practice for stem cells and stem-cell-derived models. ALTEX. 34(1):95-132. https://doi.org/10.14573/altex.1607121

Planchart A, Mattingly CJ, Allen D, Ceger P, Casey W, Hinton D, Kanungo J, Kullman SW, Tal T, Bondesson M, Burgess SM, Sullivan C, Kim C, Behl M, Padilla S, Reif DM, Tanguay RL, Hamm J. 2016. Advancing toxicology research using in vivo high throughput toxicology with small fish models. ALTEX. 33(4):435-452. https://doi.org/10.14573/altex.1601281
Recognized as an NIEHS Intramural Paper of the Month, September 2016

Polk WW, Sharma M, Sayes CM, Hotchkiss JA, Clippinger AJ. 2016. Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface. Part Fibre Toxicol. 13(1):20. https://doi.org/10.1186/s12989-016-0131-y

Russo DP, Kim MT, Wang W, Pinolini D, Shende S, Strickland J, Hartung T, Zhu H. 2017. CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data. Bioinformatics. 33(3):464-466. https://doi.org/10.1093/bioinformatics/btw640

Strickland J, Zang Q, Kleinstreuer N, Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W. 2016. Integrated decision strategies for skin sensitization hazard. J Appl Toxicol. 36(9):1150-1162. https://doi.org/10.1002/jat.3281
Recognized as an NIEHS Intramural Paper of the Month, October 2016

Strickland J, Zang Q, Paris M, Lehmann DM, Allen D, Choksi N, Matheson J, Jacobs A, Casey W, Kleinstreuer N. 2017. Multivariate models for prediction of human skin sensitization hazard. J Appl Toxicol. 37(3):347-360. https://doi.org/10.1002/jat.3366

Tal T, Kilty C, Smith A, LaLone C, Kennedy B, Tennant A, McCollum CW, Bondesson M, Knudsen T, Padilla S, Kleinstreuer NC. 2017. Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. Reprod Toxicol. 70:70-81. https://doi.org/10.1016/j.reprotox.2016

Toman B, Rosslein M, Elliott JT, Petersen EJ. 2016. Estimation and uncertainty analysis of dose response in an inter-laboratory experiment. Metrologia 53:S40-S45. https://doi.org/10.1088/0026-1394/53/1/S40

Wagner L, Isbrucker R, Locht C, Arciniega J, Costanzo A, McFarland R, Oh H, Hoonakker M, Descamps J, Andersen SR, Gupta RK, Markey K, Chapsal JM, Lidster K, Casey W, Allen D. 2016. In search of acceptable alternatives to the murine histamine sensitsation test (HIST): what is possible and practical? Pharmeur Bio Sci Notes. 2016:151-170.

Zang Q, Mansouri K, Williams A, Judson R, Allen D, Casey W, Kleinstreuer N. 2017. In silico prediction of physicochemical properties of environmental chemicals using molecular fingerprints and machine learning. J Chem Inf Modeling. 57:(1)36-49. https://doi.org/10.1021/acs.jcim.6b00625
Recognized as an NIEHS Intramural Paper of the Month, April 2017

Zang Q, Paris M, Lehmann DM, Bell S, Kleinstreuer N, Allen D, Matheson J, Jacobs A, Casey W, Strickland J. 2017. Prediction of skin sensitization potency using machine learning approaches. J Appl Toxicol. 37(7):792-805. https://doi.org/10.1002/jat.3424

Zhu H, Bouhifd M, Kleinstreuer N, Kroese ED, Liu Z, Luechtefeld T, Pamies D, Shen J, Strauss V, Wu S, Hartung T. 2016. Supporting read-across using biological data. ALTEX. 33(2):167-182. https://doi.org/10.14573/altex.1601252

Abstracts

Adams K. 2017. Finding funding opportunities in 3Rs research [Abstract No. 792]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):171.

Allen D. 2016. Integrating alternative methods within a regulatory framework and the impact of AOPs in designing an integrated testing strategy to replace repeat exposure inhalation toxicity [Abstract No. 1705]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):165.

Allen D, Wilson D, Hotchkiss J, Morefield S, Casey W, Clippinger A. 2017. Integrating alternative approaches to replace animals in inhalation toxicity testing [Abstract No. 201]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):86.

Alzualde A, Alday A, Behl M, Tice RR, Paules R, Muriana A, Quevedo C. 2016. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays [Abstract No. 2456]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):344.

Auerbach SS, Phillips J, Svoboda DL, Yang L, Kuo B, Thomas RS, Yauk CL, Shah RR, Paules R. 2017. Evaluation of parameter settings in genomic benchmark dose analysis that minimize false discovery and maximize reproducibility [Abstract No. 2922]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):453.

Bell S, Burgoon L, Phillips J, Allen D, Casey W, Kleinstreuer N. 2017. A new tool for aligning assay endpoints to adverse outcome pathways [Abstract No. 207]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):155.

Bell S, Burgoon L, Phillips J, Ceger P, Allen D, Casey W, Kleinstreuer N. 2017. A new tool for aligning assay endpoints to adverse outcome pathways. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Bell S, Phillips J, Sedykh A, Sprankle C, Morefield S, Allen D, Casey W, Kleinstreuer N. 2017. An integrated chemical environment to support 21st century toxicology [Abstract No. 2935]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):456.

Bone A, Xia M, Sakamuru S, Huang R, Houtman R, van Beuningen R, Watt E, Kleinstreuer N, Judson R, Houck K. 2017. Identification of androgen receptor antagonists using Tox21 qHTS data and the MARCoNI assay [Abstract No. 1636]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):149.

Boyd WA, Pirone JR, Shaw MP, Kleinstreuer NC, Martin MT, Rashid A, Fostel JM, Thayer KA. 2017. Identification of environmental chemicals with potential roles in obesity and diabetes using animal studies from U.S. EPA and NTP toxicological databases [Abstract No. 3163]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):508.

Browne P. 2016. Screening chemicals for estrogen bioactivity using computational approaches [Abstract No. 1726b]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):170.

Cagle P, Padilla S, Tennant A, Tal T, Hedge J, Chorley B, Angrish M. 2017. An embryonic zebrafish screening model for early life-stage obesity [Abstract No. 2212]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):286.

Casey W. 2017. Funding research and validation of alternative methods in the United States [Abstract No. 806]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):171.

Casey W. 2017. A new strategic roadmap to establish new approaches for evaluating the safety of chemicals and medical products in the United States [Abstract No. 739]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):247.

Casey W. 2016. Strategy for implementing the vision of toxicity testing in the 21st century [Abstract]. Presented at the Fifth Annual Meeting of the American Society of Cellular and Computational Toxicology; Research Triangle Park, NC; 29-30 September 2016.

Casey W. 2017. Update from the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) [Abstract No. 738]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):233.

Ceger P, Choksi N, Hamm J, Truax J, Daniel A, Allen D, Sutherland V, McIntyre B, Foster P, Maull E, Casey W. 2017. Development of a curated database of in vivo developmental toxicity data [Abstract No. 3159]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):507.

Chang X, Bell SM, Pirone JR, Allen D, Casey W, Kleinstreuer N. 2017. Open-source workflows for in vitro to in vivo extrapolation [Abstract No. 3185]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):513.

Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, Wetmore BA, Ferguson S, DeVito MJ, Allen D, Casey W. 2016. In vitro to in vivo extrapolation for estrogenic activity of environmental chemicals [Abstract No. 2224]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):288.

Chang X, Pirone J, Bell SM, Allen D, Casey W, Kleinstreuer N. 2016. An open-source workflow for in vitro to in vivo extrapolation [Abstract]. Presented at the Fifth Annual Meeting of the American Society of Cellular and Computational Toxicology; Research Triangle Park, NC; 29-30 September 2016.

Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N. 2017. An open-source IVIVE workflow integrating QSAR and PK models [Abstract No. 203]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):197.

Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N. 2017. An open-source IVIVE workflow integrating QSAR and PK models [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Craig E, Perron M, Pope-Varsalona H, Lowit A. 2016. Implementation of the screening framework for cumulative risk assessment of pesticides [Abstract No. 2690]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):397.

Elespuru R, Pfuhler S, Aardema MJ, Chen T, Doak S, Doherty A, Farabaugh SC, Kenny J, Manjanatha M, Ouedraogo G, Mahadevan B, Moore MM, Stankowski LR, Tanir JY. 2017. Genotoxicity assessment of nanomaterials: best practices, assays, and methods [Abstract No. 2269]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):300.

Emond C, Ruiz P, Mumtaz M. 2016. Applications of the PBPK model of dioxins to evaluate real life exposure scenarios [Abstract No. 2227]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):289.

Fang H, Xu J, Liu Z, Liu Y, Harris S, Thakkar S, Zhou G, Zhang G, Howard P, Tong W. 2016. FDALabel database: a rich resource for study of pharmacogenomics biomarkers in advancing drug safety and precision medicine [Abstract No. 2750]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):411.

Ferguson S, Ramaiahgari SC, Rice J, Dunlap P, Smith-Roe S, Witt K, Auerbach S, Merrick A, DeVito M, Paules RS. 2017. Organotypic HepaRG cultures (384-well) and high throughput transcriptomics with 112 compounds to model human liver and characterize compound-induced biological-response “space” [Abstract No. 1590]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):139.

Fitzpatrick J, Karmaus AL, and Patlewicz G. 2017. Development of an acute oral toxicity dataset to facilitate assessment of existing QSARs and development of new models [Abstract]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017.

Fitzpatrick J, Karmaus AL, Pradeep P, Patlewicz G. 2017. Development of an acute oral toxicity dataset to facilitate assessment of existing QSARs and development of new models [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Fitzpatrick S. 2017. Advancing FDA regulatory science through innovation [Abstract No. 3124]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):499.

Fitzpatrick S. 2017. Advancing regulatory toxicology at the FDA [Abstract No. 805]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):73.

Fitzpatrick S. 2017. FDA CFSAN: modernizing approaches to regulatory toxicity testing [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Fitzpatrick S. 2017. Incorporating in vitro reproductive and developmental assays into regulatory risk assessment [Abstract No. 1611]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):143.

Fitzpatrick S. 2017. Low-dose non-monotonic responses [Abstract No. 2315]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):311.

Fitzpatrick S. 2017. Qualifying new in vitro tools for use in a regulatory risk assessment [Abstract No. 1614]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):144.

Hamm J, Ceger P, Boyles R, Reif D, Burgoon L, Haendel M, Walker N, Maull EA. 2017. Implementation of zebrafish ontologies for toxicology screening [Abstract No. 209]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):67.

Hamm J, Ceger P, Maull E, Padilla S, Perkins E, Planchart A, Stedman D, Tal T, Tanguay R, Volz D, Baker G, Stout M, Walker N. 2017. SEAZIT: the National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology [Abstract No. 3161]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):507.

Hanna SK, Montoro Bustos AR, Peterson AW, Relpa V, Scanlan LD, Hosbas Coskun S, Cho TJ, Johnson ME, Hackley VA, Nelson BC, Winchester MR, Elliott JT, Petersen EJ. 2017. Positively charged nanoparticles lead to artifacts in a Caenorhabditis elegans toxicity assay [Abstract No. 1313]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):75.

Hedge JM, Jarema KA, Hunter DL, Padilla S. 2016. Strain-specific changes in locomotor behavior in larval zebrafish elicited by cholinergic challenge [Abstract No. 1795]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):186.

Houck K, Mosher S, Judson R, Wambaugh J, Martin M, Padilla S. 2016. Toxicity screening of a subset of the ToxCast Phase III chemical library using a zebrafish developmental assay [Abstract No. 1803]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):188.

Hsieh J-H, Huang R, Tice R, Paules R, Xia M, Auerbach S. 2016. Real-time cell viability profiling of Tox21 10K compounds [Abstract No. 1095]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):22.

Huppelschoten S, Niemeijer M, dem Hollander W, Baze A, Parmentier C, Paules R, Richert L, van de Water B. 2017. Gene expression profiling of primary human hepatocyte inter-individual variance in adaptive stress response activation [Abstract No. 2541b]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):363.

Jacobs A. 2016. CDER acceptance of alternative assays [Abstract No. 2574]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):370.

Jacobs A. 2017. International 3Rs efforts for pharmaceuticals and other products [Abstract No. 133]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):235.

Jaworska J, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M. 2016. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment – a decision support system for quantitative weight of evidence and adaptive testing strategy [Abstract No. 2196]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):281.

Karmaus A, Allen D, Kleinstreuer N, Casey W. 2017. Characterizing variability across rat oral acute toxicity studies: implications for alternative model development [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Karmaus A, Allen D, Kleinstreuer N, Casey W. 2017. Characterizing the variability of LD50 values in acute toxicity studies: implications for alternative methods development [Abstract No. 205]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):221.

Klaric M, Alepee N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Del Bufalo A, Gellatly N, Goebel C, Hoffmann S, Kern P, Kleinstreuer N, Kuehnl J, Mewes K, Miyazawa M, Petersohn K, Strickland J, Van Vliet E, Zang Q. 2017. Cosmetics Europe assessment of non-animal approaches for predicting skin sensitization [Abstract No. 43]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):94.

Kleinstreuer N. 2017. In vitro insights into chemical carcinogenesis. [Abstract No. 802]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):64.

Kleinstreuer N. 2017. A strategy to ensure relevant science for regulatory acceptance and industry adoption. [Abstract No. 453]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):246.

Kleinstreuer N. 2017. Developmental toxicity potency of valproate analogues in a human pluripotent stem cell-based assay [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Kleinstreuer N. 2017. Pathway-based models to predict developmental and reproductive toxicologies. [Abstract No. 3074]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):489.

Kleinstreuer N. 2016. Skin sensitization testing strategy evaluation [Abstract No. 2533]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):361.

Kleinstreuer N, Ceger P, Allen D, Browne P, Houck K, Martin M, Thomas R, Dix D, Casey W, Judson R. 2016. Development and validation of a computational model for androgen receptor activity [Abstract]. Presented at the Fifth Annual Meeting of the American Society of Cellular and Computational Toxicology; Research Triangle Park, NC; 29-30 September 2016.

Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W. 2016. Development and application of a reference database for androgen receptor activity [Abstract No. 2651]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):388.

Kleinstreuer N, Strickland J, Zuang V, Lowit A, Matheson J, Allen D, Casey W, Whelan M. 2017. Evaluating defined approaches to testing and assessment of skin sensitization potential [Abstract No. 3160]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):507.

Lowit A. 2017. EPA-OPPs initiative to modernize the acute “6-pack” [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Lowit A. 2017. Regulatory perspective: how do regulatory authorities currently utilize MOA data to make decisions about human relevancy? [Abstract No. 2728]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):143.

Lowit A, Schlosser C, Myska A, Patlewicz G, Paris M, Karmaus A, Strickland J, Allen D, Kleinstreuer N, Casey W. 2017. Replacing animals for acute systemic toxicity testing: a U.S. strategy and roadmap [Abstract No. 2182]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):279.

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Xia M. 2017. Androgen receptor agonist identification and characterization by screening the Tox21 10K compound library [Abstract No. 1511]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):120.

Mansouri K, Kleinstreuer N, Watt E, Harris J, Judson R. 2017. CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity [Abstract No. 1389]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):93.

Martin WK, Padilla S, Kim YH, Hays MD, Hunter DL, Hazari MS, Gilmour MI, Farraj AK. 2017. Zebrafish locomotor responses predict irritant potential of smoke particulate matter from five biomass fuels [Abstract No. 2457]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):343.

Miller M, Goodson WH, Lowe L, Manjili MH, Kleinstreuer N, Bisson WH. 2017. Integrating the low-dose mixture hypothesis of carcinogenesis into the future of cancer research. [Abstract No. 1103]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):24.

Moser V, Padilla S. 2016. Esterase detoxification of acetylcholinesterase inhibitors by human liver samples in vitro [Abstract No. 2886]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):442.

Ono A, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Sozu T, Nakayama T, Kusao T, Kawakami T, Kojima K, Kojima H, Richmond J, Kleinstreuer N, Bae-Hwa K, Yamamoto Y, Fujita M, Kasahara T. 2017. Phase-1 of the validation study of amino acid derivative reactivity assay (ADRA): A novel in chemico alternative test methods of skin sensitization [Abstract No. 231]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):99.

Padilla S, Waalkes M, Hedge JM, Hunter DL, Jarema K. 2017. Comparison of the developmental and acute neurotoxicity of a library of organophosphorus pesticides using a vertebrate behavioral assay [Abstract No. 2641]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1) 386.

Palmer J, Smith A, Burrier R, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer N. 2017. Developmental toxicity potency of valproate analogues in a human pluripotent stem cell-based assay [Abstract No. 631]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):46.

Pamies D, Bal-Price A, Coecke S, Allen D, Stacey G, Gstraunthaler G, Leist M, Hartung T. 2017. Good cell culture practice (GCCP 2.0) [Abstract No. 598]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):192.

Paris M, Strickland J, Allen D, Casey W. 2016. Retrospective analysis of acute toxicity tests for pesticides [Abstract No. 2990]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):467.

Paules R. 2017. Implementing approaches for moving Tox21 towards quantitative systems toxicology [Abstract No. 3114]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):497.

Paules R. 2017. The future of Tox21: changing the NTP landscape [Abstract No. 790]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):20.

Paules R, Hsieh J-H, Smith-Roe S, Witt KL. 2017. High-throughput approaches for characterizing genotoxicity and carcinogenic potential: bridging classic and high-throughput approaches [Abstract No. 819]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):64.

Perron M, Lowit A, Smith C, Wilbur D. 2016. Development of a screening framework for pesticide cumulative risk assessment [Abstract No. 2689]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):397.

Quevedo C, Alzualke A, Alday A, Irjalba I, Holgado O, Muriana A, Ryan K, Paules R, Behl M. 2017. Toxicity profiling using a battery of assays in zebrafish embryos including teratogenicity, behavior, cardiotoxicity, ototoxicity, and hepatotoxicity [Abstract No. 2792]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):422.

Ramaiahgari SC, Walkyanatha S, Boyd W, DeVito MJ, Paules RS, Ferguson SS. 2016. Metabolically competent HepaRG spheroid model for in vitro toxicology studies [Abstract No. 2179]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):277.

Ramaiahgari SC, Walkyanatha S, Dixon D, DeVito MJ, Paules RS, Ferguson SS. 2017. High-dimensional toxicological assessment of chemical exposure on physiologically relevant 3D in vitro models [Abstract No. 1589]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):139.

Rowlands JC, Walker N. 2016. Bioactivity-based margin of exposure safety assessment: the next stop along the road to 21st century safety assessments [Abstract No. 1767a]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):179.

Scarano L. 2017. Progress report on development of the strategic plan to reduce, refine or replace use of vertebrate animal testing under the Lautenberg Act [Abstract]. Presented at the Sixth Annual Meeting of the American Society of Cellular and Computational Toxicology; Gaithersburg, MD; 21-22 September 2017.

Schnackenberg LK, Sun J, Breenhaw J, Bhattacharyya S, Gill P, Salminen WF, Mendrick DL, James LP, Beger RD. 2016. Translational biomarkers of acetaminophen-induced hepatotoxicity in urine samples [Abstract No. 1110]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):25.

Stevens J, DeMarini D, Hazari MS, Hunter DL, Padilla S, Farraj AK. 2016. Zebrafish locomotor responses demonstrate irritant effect of fine particulate matter sources and a role for TRPA1 [Abstract No. 2252]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):165.

Strickland J, Karmaus AL, Chang X, Paris M, Allen D, Kleinstreuer N, Casey W. 2017. Correlation of in vitro cytotoxicity and acute toxicity [Abstract No. 198]. Presented at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences; Seattle, WA; 20-24 August 2017. ALTEX Proceedings. 6(1):35.

Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N. 2017. Prediction of skin sensitization potency using machine learning approaches [Abstract No. 2915]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):451.

Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N. 2016. Prediction of skin sensitization potency using machine learning approaches [Abstract]. Presented at the Fifth Annual Meeting of the American Society of Cellular and Computational Toxicology; Research Triangle Park, NC; 29-30 September 2016.

Strickland J, Zang Q, Paris M, Lehmann DM, Kleinstreuer N, Allen D, Choksi N, Matheson J, Jacobs A, Lowit A, Casey W. 2016. Multivariate models for prediction of human skin sensitization hazard [Abstract No. 2202]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):283.

Walker N. 2016. Biological canaries in the coal mine: strategic implications for utilizing bioactivity-based margins of exposure in human health risk assessment [Abstract No. 1767b]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):179.

Wilson VS, Conley J, Evans N, Cardon M, Rosenblum L, Iwanowicz LR, Hartig PC, Schenck K, Bradley PM. 2017. In vitro assessment of estrogen, androgen, and glutocorticoid bioactivity in a nationwide screen of United States stream waters [Abstract No. 1638]. Presented at the 56th Annual Meeting of the Society of Toxicology; Baltimore, MD; 12-16 March 2017. Toxicol Sci/Toxicologist. 156(1):149.

Yang C, Casey W, Choksi N, Ceger P, Kleinstreuer N, Allen D, Dharshan P, Bittner G. 2016. An in vitro test method for screening potential androgenic agonists and antagonists in MDA-kb2 cells [Abstract No. 3905]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):S176.

Yao J, Jones Y, Monroe W, Collins J, Howard P, Patri AK, Zhang Y. 2016. Size and crystal structure dependent inhibition of human mesenchymal stem cell adipogenic differentiation by nanoscale titanium dioxide [Abstract No. 2774]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):417.

Zang Q, Allen D, Casey W, Judson R, Kleinstreuer N. 2016. QSAR modeling to predict androgen receptor pathway activity [Abstract No. 1098]. Presented at the 55th Annual Meeting of the Society of Toxicology; New Orleans, LA; 13-17 March 2016. Toxicol Sci/Toxicologist. 150(1):23.

Articles in the NIEHS Environmental Factor Newsletter

Guidry V. September 2016. Research needed on low-dose mixtures and cancer. Environmental Factor [Internet].

Hood E. November 2016. New initiative to modernize regulatory toxicity testing. Environmental Factor [Internet].

Hood E. January 2017. Research collaborations take center stage at NTP board meeting. Environmental Factor [Internet].

Sprankle C. January 2016. Casey recognized for contributions to animal welfare. Environmental Factor [Internet].

Sprankle C. March 2016. Teratology Society recognizes Kleinstreuer. Environmental Factor [Internet].

Sprankle C. June 2016. Kleinstreuer highlights groundbreaking approaches to safety testing. Environmental Factor [Internet].

Sprankle C. July 2016. Plan to replace animal use shared at public forum. Environmental Factor [Internet].

Sprankle C. November 2016. Experts address the challenge of inhalation toxicity testing. Environmental Factor [Internet].

Sprankle C. December 2016. Kleinstreuer receives Lush Prize Young Researcher award. Environmental Factor [Internet].

Sprankle C. March 2017. NIEHS grantee validates tissue chips for toxicity testing. Environmental Factor [Internet].

Sprankle C. June 2017. Public forum on alternatives to animal testing highlights next steps. Environmental Factor [Internet].

Sprankle C. August 2017. New technologies highlighted at toxicology meeting. Environmental Factor [Internet].

Sprankle C. September 2017. International meeting highlights NTP efforts to replace animal tests. Environmental Factor [Internet].

Sprankle C. October 2017. Speeding the adoption of alternative safety tests. Environmental Factor [Internet].

Sprankle C. December 2017. Scientists invited to build computer models that predict toxicity. Environmental Factor [Internet].