Key accomplishments of ICCVAM and ICCVAM member agencies in support of the ICCVAM mission during 2018 and 2019 include:
Publication of ICCVAM Strategic Roadmap. This document, developed with participation from the 16 ICCVAM member agencies, describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. To facilitate access to the roadmap by ICCVAM’s international partners, the roadmap was translated into five languages.
Development of the Collaborative Acute Toxicity Modeling Suite. The ICCVAM Acute Toxicity Workgroup organized a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. This project produced the Collaborative Acute Toxicity Modeling Suite, an online resource for screening organic chemicals for acute oral toxicity.
DoD strategic roadmap to promote the use of new approach methodologies in rapid chemical assessment. Currently in development, this DoD-specific roadmap will help laboratories across DoD to better define their chemical assessment needs and collaborate on development or refinement of appropriate non-animal approaches for testing.
EPA draft policy on non-animal methods for skin sensitization. In 2018, EPA announced a draft science policy to reduce animal use in testing strategies that evaluate chemicals for their ability to cause an allergic reaction, inflammation, or sensitization of the skin. The draft policy was the result of national and international collaboration.
EPA initiatives to reduce animal use. In 2019, EPA announced a directive to prioritize efforts to reduce animal testing, which called for reducing mammal study requests and funding 30% by 2025 and completely eliminating them by 2035. EPA has also established criteria for waiving some types of animal study requirements.
EPA strategic plan for the Toxic Substances Control Act. In 2018, EPA released a plan for that describes how the agency will promote development and implementation of methods and strategies that reduce, refine, or replace vertebrate animal testing to provide chemical safety information required under the Toxic Substances Control Act.