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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Validation of Androgen Receptor Activity Assays

NICEATM collaborated with test method developer CertiChem, Inc. to validate an in vitro test method that uses MDA-Kb2 human breast cancer cells to measure androgen receptor agonist and antagonist activity. Specifically, NICEATM provided guidance on incorporating a cytotoxicity assay into the test method protocol. Testing of 67 coded reference chemicals in agonist and antagonist modes to characterize method reliability and relevance is finished, and a report summarizing these results was provided to CertiChem in December of 2018.