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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Collaboration with Cosmetics Europe to Evaluate Defined Approaches for Skin Sensitization

NICEATM and Cosmetics Europe collaborated to evaluate multiple defined approaches for skin sensitization safety assessment that had been submitted to OECD. The collaboration produced two publications:

  • Hoffman et al. 2018 describes a database including data from human, animal, and five non-animal tests for 128 substances. The substances in the database have a variety of chemical structures and use categories. The database is a proposed point of reference for the evaluation and development of new non-animal approaches to skin sensitization safety assessment.
  • Kleinstreuer et al. 2018 describes an analysis of multiple defined approaches for skin sensitization safety assessment of cosmetic ingredients using the database described in Hoffman et al. Many of these approaches were found to perform as well or better than animal methods to predict human skin sensitization hazards.

Based on the results of these analyses, NTP has adopted in vitro skin sensitization methods and associated defined approaches as the default approach to assess the potential for chemicals to cause allergic contact dermatitis.