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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/884552

In Vitro Testing to Support Development of Defined Approaches for Eye Irritation of Agricultural Products

NICEATM, the PETA International Science Consortium Ltd., EPA, and CropLife America member companies are collaborating to develop an in vitro defined approach for hazard classification of eye irritation potential of agrochemical formulations. A three-phased prospective evaluation was designed to (1) assess the applicability of seven in vitro eye irritation/corrosion protocols to agrochemical formulations and (2) develop a defined approach for agrochemical formulations testing for prediction of U.S. and international irritancy classifications. In Phase 1, completed in 2018, six formulations were tested in seven different eye irritation test protocols. Ten additional agrochemical formulations with in vivo data representing a wider range of eye irritation classifications were evaluated in Phase 2 during 2019. While none of the methods directly correlated with the in vivo results, several methods showed potential for use in a defined approach. Analysis of the data from Phases 1 and 2 will determine the next steps of the study. An abstract describing this work (Choksi et al.) was accepted for presentation at the 2020 Society of Toxicology annual meeting.

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