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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

ICCVAM Communities of Practice Webinars

In 2015, ICCVAM initiated a series of Communities of Practice webinars to provide opportunities for detailed presentations on a current topic relevant to alternative test method development.

  • The fourth of these webinars, presented on Jan. 23, 2018, was titled Machine Learning in Toxicology: Fundamentals of Application and Interpretation. The webinar, viewed by nearly 200 people, explored the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that should be taken when evaluating their output. Sean Ekins, Ph.D., D.Sc., Collaborations Pharmaceuticals, Inc., and NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., addressed issues specific to machine learning approaches used in a regulatory context. Case studies were presented to highlight where such techniques have been applied successfully both nationally and internationally.
  • Nearly 250 viewers attended the Jan. 22, 2019, Communities of Practice webinar, Non-animal Approaches for Inhalation Toxicity Testing. Amy Clippinger, Ph.D., PETA International Science Consortium Ltd., provided an overview of several ongoing collaborative efforts associated with acute and subchronic inhalation toxicity testing, with emphasis on available human cell-based and in silico methodologies, considerations of dosimetry, and development of technologies that could provide predictive test methods in the future. Paul Hinderliter, Ph.D., DABT, Syngenta Crop Protection, Inc., presented a case study describing a source-to-outcome approach that uses in vitro and in silico methods to refine inhalation risk assessment for point of contact toxicity.