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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Additivity Approaches to Predicting Toxicity of Formulations

The EPA Office of Pesticide Programs has been accepting voluntary submissions of oral and inhalation toxicity data for agrochemical formulations under a pilot program to evaluate the usefulness and acceptability of a mathematical tool that estimates the toxicological classification of a chemical mixture. The submitted data were paired with toxicity calculations done in accordance with the GHS additivity equation based on the individual components of the formulation. NICEATM is evaluating the extent to which predictions of acute toxicity for a formulation derived using the additivity equation compare to in vivo test results. The evaluation will be finalized in 2020 along with a report describing the results.