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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Message from NICEATM and ICCVAM

On behalf of ICCVAM and NICEATM, we are pleased to present the 2018-2019 ICCVAM Biennial Progress Report. This report provides the most comprehensive overview ever of activities by ICCVAM and its 16 member agencies that support the ICCVAM mission. Published on the 20th anniversary of the ICCVAM Authorization Act, this report for the first time includes contributions from all 16 ICCVAM agencies describing their efforts to reduce, refine, and replace animal testing.

Our primary focus since the January 2018 publication of the Strategic Roadmap has been to implement the roadmap goals for acute systemic toxicity, skin and eye irritation, and skin sensitization. Recent ICCVAM activities advanced both development of new approaches for assessing these endpoints and regulatory initiatives to encourage use of non-animal approaches for acute toxicity testing.

This Biennial Report also summarizes activities to explore non-animal approaches for more complex endpoints, such as developmental toxicity and carcinogenicity testing, and resources to support development of 21st century testing approaches and computational toxicology capabilities. These include improvements to NICEATM’s Integrated Chemical Environment, exploration of new approaches to validation, development of machine learning approaches for modeling toxicity endpoints and extraction of literature data, and analyses of variability of legacy in vivo data.

ICCVAM continues to expand outreach efforts to raise awareness of available alternative methods and foster partnerships with stakeholders. ICCVAM convened two Public Forum meetings, which generated productive interactions and allowed ICCVAM agency representatives to present updates on activities. Public meetings of SACATM focused on substantive strategic and technical discussions to leverage the SACATM members’ expertise in advancing the ICCVAM mission. This report also provides summaries of two ICCVAM Communities of Practice webinars and over a dozen workshops, webinars, or webinar series presented by ICCVAM agencies that focused on alternatives to animal testing. Many of these were organized in collaboration with nongovernment stakeholders, further strengthening relationships with these groups.

Many of the accomplishments described herein would not have been realized without the visionary leadership of Linda Birnbaum, Ph.D., who retired last year as director of NIEHS. We thank her for the support and direction she provided to NICEATM and ICCVAM. We would also like to gratefully acknowledge the contributions of the representatives and interagency working group members from the 16 ICCVAM member agencies, as well as contributions of NICEATM and its contract staff at Integrated Laboratory Systems, the members of SACATM, and our many other stakeholders.

The activities summarized in this report exemplify ICCVAM’s ongoing commitment to working with U.S. and international partners to advance development and acceptance of new scientifically valid test methods that will reduce and eventually replace animal use. We look forward to continued progress and effective interactions with our stakeholders in the coming years.

Anna Lowit, Ph.D.
Co-Chair, ICCVAM
Office of Pesticide Programs within the
Office of Chemical Safety and Pollution Prevention
U.S. Environmental Protection Agency

Emily Reinke, Ph.D., DABT
Co-Chair, ICCVAM
Toxicology Directorate
U.S. Army Public Health Center

Warren Casey, Ph.D., DABT
Administrative Director, ICCVAM
National Institute of Environmental Health Sciences

Nicole Kleinstreuer, Ph.D.
Acting Director, NICEATM
National Institute of Environmental Health Sciences

ICCVAM Co-chair Emily Reinke

ICCVAM Co-chair Emily Reinke, Ph.D., DABT

ICCVAM Administrative Director Warren Casey, Ph.D.

ICCVAM Administrative Director Warren Casey, Ph.D., DABT

Acting NICEATM Director Nicole Kleinstreuer

Acting NICEATM Director Nicole Kleinstreuer, Ph.D.