In February 2019, FDA announced policies aimed at modernizing the oversight and regulation of dietary supplements. Among the steps FDA is taking to implement these policies include collaboration with industry to support the development of new products, ingredients, and delivery systems while protecting public health and safety. To support this collaboration, FDA, NIEHS, and the non-profit Health and Environmental Sciences Institute signed a memorandum of understanding establishing the Botanical Safety Consortium. The consortium includes over 20 participants from industry, academia, and government to promote scientific advances in evaluating the safety of botanical ingredients and mixtures in dietary supplements. This group will look at novel ways to use cutting-edge toxicology tools, including alternatives to animal testing, to promote the goals of safety and effectiveness.