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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Other EPA Collaborations with Stakeholders

EPA has formed strategic partnerships with organizations in multiple sectors to encourage the use of alternative toxicity testing methods in decision making. These activities will lead to more timely chemical evaluations that may better inform protection of human health and the environment.

  • EPA is collaborating with NICEATM and international partners on an analysis of dermal absorption data to assess the feasibility of using data from in vitro studies alone to estimate dermal absorption.
  • EPA is collaborating with NICEATM, the PETA International Science Consortium Ltd., and CropLife America member companies to develop an in vitro defined approach for hazard classification of eye irritation potential of agrochemical formulations.
  • EPA collaborated with Syngenta to support development of a 3D in vitro inhalation toxicity model to derive a point of departure for inhalation toxicity for the fungicide chlorothalonil.
  • EPA is working with Unilever to advance chemical safety for consumer products through case studies focused on five chemicals. The goal of the collaboration is to develop new, more efficient approaches for chemical hazard assessment, including high-throughput transcriptomics. The case studies are using new chemical data, such as data from ToxCast, to evaluate chemicals.
  • EPA and Proctor & Gamble are collaborating to advance the use of a new technology developed by EPA researchers that incorporates metabolic competency into HTS assays.
  • EPA is collaborating with the Minnesota Department of Health to use alternative approaches to evaluate chemicals in drinking water.
  • A retrospective study conducted by EPA and People for the Ethical Treatment of Animals explored the quantitative and qualitative contributions of risk assessment methods using single oral dose and subacute dietary toxicity endpoints to the overall conclusions of acute avian risk.

Details of these and other projects can be found on EPA’s Collaborative Agreements for Computational Toxicology Research webpage.