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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Activities of the Tri-Services Toxicology Consortium

The mission of the Tri-Services Toxicology Consortium is to communicate, coordinate, and optimize toxicology needs throughout DoD by providing a central point of contact to DoD toxicology resources. The Consortium currently includes over 200 individuals from 11 organizations within DoD, seven of which have laboratories.

The Consortium convened three meetings during 2018 and 2019. These meetings supported ongoing efforts in improving in silico predictions of molecular targets, understanding of toxicant/microbiome interactions, and development and use of NAMs in phased approaches to toxicity data collection and hazard assessment. Significant recent accomplishments include:

  • A DoD instruction that established the Consortium as a technical organization authorized and directed by the Deputy Assistant Secretary of Defense for Environment to participate in technical reviews and evaluation of techniques and methods for toxicology assessments.
  • Substance-specific technical reviews concerning chromium, antimony trioxide, di(2-ethylhexyl) phthalate and hexamethylenetramine, trichloroethylene, and PFAS.
  • Establishment of DoD technical representation on relevant government and scientific committees.
  • Development of a draft DoD Strategic Roadmap to Promote the Use of New Approach Methodologies in Rapid Chemical Hazard Assessment.