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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Safer Chemicals Research Grants

EPA funds safer chemicals research grants supporting the development of innovative science to support safer, more sustainable use of chemicals in consumer products and chemicals used for other purposes such as pesticides. Using safer, more sustainable chemicals will help to better protect human and environmental health, including sensitive populations like children, elderly, and endangered species. Much of the research funded by these grants also supports the development of alternatives to animal testing.

The following grants under this program were announced or funded during 2018 and 2019:

  • Advancing Actionable Alternatives to Vertebrate Animal Testing for Chemical Safety Assessment: promoted the development and use of alternative test methods and strategies that reduce, refine, or replace vertebrate animal testing, including analog/read-across techniques, mathematical models, and tiered-testing approaches. Five grants were awarded for projects in the areas of developmental toxicity, reproductive toxicity, or ecotoxicity testing, with funding beginning in August 2019.
  • Systems-Based Research for Evaluating Ecological Impacts of Manufactured Chemicals: funded development of innovative methods to better understand and predict biological and ecological consequences of exposures to manufactured chemicals in environmental systems. Three of the six projects funded by this program were completed in 2018 and 2019; the remaining three grants continue through 2020.
  • Organotypic Culture Models for Predictive Toxicology: established research centers to guide the development and evaluation of organotypic culture models to accelerate translational research in predictive toxicology. Four centers were funded beginning in December 2014; funding for two centers concluded in 2019, while two centers will continue to be funded into 2020.
  • New Methods in 21st Century Exposure Science: supported research to advance methods for characterizing real-world human exposure to chemicals associated with consumer products in indoor environments. Five projects were funded beginning in 2014; funding for four projects extended into 2018.