U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.


ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations

Toxicokinetics describes the absorption, distribution, metabolism, and excretion of chemicals and their metabolites by the body. In July 2019, EPA requested applications for a new funding opportunity, Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations. The goal of this funding was to improve the development of chemical toxicokinetic tools and approaches for broader applicability during chemical evaluations. Of particular interest were projects that would increase throughput and predictivity of current IVIVE approaches while reducing the uncertainty of these approaches. Awardees for the grant will be announced in spring 2020.