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ICCVAM Biennial Report 2018-2019

ICCVAM Biennial Report 2018-2019

Accelerating the Pace of Chemical Risk Assessment

The advent of NAMs for generating safety information on chemicals provides an opportunity to assess what chemical risk assessment should look like in the 21st century. EPA has a leadership role in Accelerating the Pace of Chemical Risk Assessment (APCRA; Kavlock et al. 2018), an international activity designed to bring together regulators from key international regulatory agencies such as the European Chemicals Agency and Health Canada to discuss progress in applying the new tools to prioritization, screening, and application to quantitative risk assessment of differing levels of complexity. An APCRA workshop hosted by EPA in 2019 further developed the case studies initially considered at workshops in 2016 and 2017 on the development and applications of NAMs for chemical risk assessment; an online workshop is planned for early 2020. These collaborations will examine how NAMs might transform regulatory evaluation of chemicals and help to overcome barriers to acceptance by increasing confidence in the use and acceptance of NAMs in regulatory chemical risk assessment.