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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Publication of Strategic Roadmap

In January 2018, ICCVAM published "A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States." It describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. ICCVAM coordinated the development of this document during 2017 with participation from the 16 ICCVAM member agencies and multiple interagency workgroups, as well as input from a broad range of stakeholder groups. The Strategic Roadmap describes a new framework that will enable development, establish confidence in, and ensure use of new approaches to toxicity testing that improve human health relevance and reduce or eliminate the need for testing in animals. To facilitate access to the roadmap by ICCVAM’s international partners, the roadmap was translated into five languages in 2018. Progress towards the roadmap goals during 2018 and 2019 focused on replacing or reducing animal use for acute toxicity endpoints. Relevant activities are described throughout this document.