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In June 2018, EPA published its Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Within the TSCA Program. The document describes how EPA will promote development and implementation of methods and strategies that reduce, refine, or replace vertebrate animal testing to provide chemical safety information required under the Toxic Substances Control Act (TSCA). The core components of the plan are (1) identifying, developing, and integrating NAMs for TSCA decisions; (2) building confidence that the NAMs are scientific, reliable, and relevant for TSCA decisions; and (3) implementing the reliable and relevant NAMs for TSCA decisions.
The 2018 Strategic Plan established a TSCA NAM Team to take advantage of experts/resources within the Agency to implement the plan. EPA’s long-term goal is to move towards making TSCA decisions with NAMs to reduce and eventually eliminate vertebrate animal testing for TSCA.
A 2016 update of TSCA required EPA to develop “a list, which the Administrator shall update on a regular basis, of particular alternative test methods or strategies the Administrator has identified that do not require new vertebrate animal testing and are scientifically reliable, relevant, and capable of providing information of equivalent or better scientific reliability and quality to that which would be obtained from vertebrate animal testing.” EPA issued the original list required under TSCA in June 2018 with the Strategic Plan, and issued an update of the list in December 2019.