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In the 2018-2019 Biennial Report, we are pleased to share with you the many accomplishments of NICEATM, ICCVAM, and the ICCVAM agencies to address needs and priorities identified in the Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. In particular, we highlight continued efforts to eliminate animal use for acute toxicity testing with important progress in skin sensitization assessment and an international partnership to develop the Collaborative Acute Toxicity Modeling Suite. Other efforts have leveraged alternative approaches such as high-throughput screening and computational tools to address the evaluation of complex endpoints including carcinogenicity, developmental toxicity, and neurotoxicity. Achievements noted at EPA and FDA have further advanced alternatives to animal testing and reductions in animal use.
A key area of the Strategic Roadmap is communication and collaboration. We applaud the progress by NICEATM and ICCVAM to expand outreach efforts that progress the acceptance and use of alternatives to animal testing. The many workshops, publications, and webinars have both raised awareness about areas with testing needs and communicated where testing approaches and solutions are available. This report highlights ICCVAM’s many efforts to inform and connect with stakeholders through national and international partnerships that advance test method development, evaluation, and acceptance.
We want to highlight the recognition of ICCVAM’s leadership by others. In 2018, ICCVAM Co-chair Anna Lowit, Ph.D., of EPA received the SOT Enhancement of Animal Welfare Award for her ICCVAM leadership and work at EPA’s Office of Pesticide Programs to improve risk assessments while reducing animal use in toxicity testing. In 2019, Suzanne Fitzpatrick, Ph.D., U.S. Food and Drug Administration’s principal representative to ICCVAM, received the SOT Enhancement of Animal Welfare Award that recognized her expertise in alternative toxicological methods and work to improve animal welfare within the field of toxicology.
As we look forward to continued progress, we note an organizational change at NICEATM. We welcome former NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., as the new Acting Director of NICEATM. Nicole was honored in 2019 with the SOT Achievement Award for her leadership and scientific contributions to alternative toxicological methods and computational toxicology. Warren Casey, Ph.D., who served as NICEATM Director from 2013 to 2019, will remain ICCVAM Administrative Director. We want to thank Warren for his dedicated service and acknowledge his key roles in developing the Strategic Roadmap and fostering collaboration with ICCVAM’s stakeholders.
We invite you to read the Biennial Report to learn more about all that’s been accomplished in the past two years to advance alternative methodologies and the 3Rs.
Rick Woychik, Ph.D.
Director, NIEHS and NTP
Brian Berridge, D.V.M., Ph.D., DACVP
Associate Director, NTP
Scientific Director, NTP Division, NIEHS