U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.


ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Acronyms and Abbreviations

3Rs: Principles of replacement, reduction, or refinement of animal use for scientific research or product safety testing

AFRL: Air Force Research Laboratory (U.S. Department of Defense)

AOP: Adverse outcome pathway

APCRAAccelerating the Pace of Chemical Risk Assessment

ATSDRAgency for Toxic Substances and Disease Registry

AWICAnimal Welfare Information Center (U.S. Department of Agriculture)

BoNTBotulinum neurotoxin

BraCVAMBrazilian Center for the Validation of Alternative Methods

CaCVAMCanadian Centre for the Validation of Alternative Methods

CATMoSCollaborative Acute Toxicity Modeling Suite

CCDC CBCU.S. Army Combat Capabilities Development Command Chemical Biological Center (U.S. Department of Defense)

CERAPP Collaborative Estrogen Receptor Activity Prediction Project

CoMPARACollaborative Modeling Project for Androgen Receptor Activity

CPSCU.S. Consumer Product Safety Commission

CVBCenter for Veterinary Biologics (U.S. Department of Agriculture)

DoDU.S. Department of Defense

DOEU.S. Department of Energy

DOIU.S. Department of the Interior

DOTU.S. Department of Transportation

DPRADirect peptide reactivity assay

DSStoxDistributed Structure-Searchable Toxicity (U.S. Environmental Protection Agency)

ELISAEnzyme linked immunosorbent assay

EPAU.S. Environmental Protection Agency

EURL ECVAMEuropean Union Reference Laboratory for Alternatives to Animal Testing

FDAU.S. Food and Drug Administration

FXRαFarnesoid X receptor alpha

GHSUnited Nations Globally Harmonized System of Classification and Labeling of Chemicals

HASPOCHazard and Science Policy Council (U.S. Environmental Protection Agency)

h-CLATHuman cell line activation test

HTSHigh-throughput screening

httkHigh-throughput toxicokinetic (software package, U.S. Environmental Protection Agency)

IATAIntegrated approach to testing and assessment

ICATMInternational Cooperation on Alternative Test Methods

ICCVAMInteragency Coordinating Committee on the Validation of Alternative Methods

ICEIntegrated Chemical Environment (National Toxicology Program)

ICHInternational Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use

ILSIntegrated Laboratory Systems, Inc.

iPSC: Induced pluripotent stem cell

IVIVEIn vitro to in vivo extrapolation

JaCVAM: Japanese Center for the Validation of Alternative Methods

KoCVAMKorean Center for the Validation of Alternative Methods

LC50In traditional acute inhalation or aquatic toxicity tests, the concentration that produces lethality in 50% of the animals tested

LD50In traditional acute dermal or oral systemic toxicity tests, the dose that produces lethality in 50% of the animals tested

MPSMicrophysiological systems

NAMNew approach methodology

NCATSNational Center for Advancing Translational Sciences (National Institutes of Health)

NCCTNational Center for Computational Toxicology (U.S. Environmental Protection Agency)

NCINational Cancer Institute (National Institutes of Health)

NICEATMNational Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods

NIEHSNational Institute of Environmental Health Sciences (National Institutes of Health)

NIHNational Institutes of Health

NIOSHNational Institute for Occupational Safety and Health

NISTNational Institute of Standards and Technology

NLMNational Library of Medicine (National Institutes of Health)

NTPNational Toxicology Program

OECDOrganisation for Economic Co-operation and Development

OPERAOpen Structure-activity/property Relationship App

OSHAOccupational Safety and Health Administration

PAHPolycyclic aromatic hydrocarbon

PBPKPhysiologically based pharmacokinetic

PETA: People for the Ethical Treatment of Animals

PFASPer- and polyfluoroalkyl substances


QSARQuantitative structure-activity relationship

SACATMScientific Advisory Committee on Alternative Toxicological Methods

SEAZITSystematic Evaluation of the Application of Zebrafish in Toxicology (National Toxicology Program)

SOTSociety of Toxicology

Tox21Collaborative effort among four U.S. Federal Government offices to develop more efficient approaches to predict how chemicals may affect human health

ToxCastToxicity Forecaster (U.S. Environmental Protection Agency)

TOXNETToxicology Data Network (National Library of Medicine)

TSCAToxic Substances Control Act (U.S. Environmental Protection Agency)

USDAU.S. Department of Agriculture

USGSU.S. Geological Survey (U.S. Department of the Interior)