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ICCVAM Biennial Report 2018-2019

ICCVAM Biennial Report 2018-2019
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https://ntp.niehs.nih.gov/go/892852

Abstracts

Allen D, Choksi N, Gehen S, Casey W, Clippinger A. 2018. Public-private partnerships to advance in vitro eye irritation testing methods and approaches. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Allen DG, Clippinger A, Morefield S, Casey WM, Ghosh C, Goode J, Brown J. 2019. Using the monocyte activation test for medical devices [Abstract No. 2469]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):350.

Anyangwe N, Fitzpatrick S, Flannery B, Mattia A, Schaefer H, Tyler T, Whiteside C. 2019. Use of dog studies in U.S. FDA’s safety assessments for food additives and color additives [Abstract No. 2781]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):419.

Balik-Meisner M, Phadke D, Mav D, Everett L, Shah R, Merrick BA, Paules R. 2019. Development of a zebrafish S1500+ sentinel gene set for high-throughput transcriptomics [Abstract No. 3178]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):490.

Beekhuijzen M, Kleinstreuer NC. 2018. Teratology Society and European Teratology Society exchange lecture: are we ready for alternative testing? Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Behl M, Ryan K, Hsieh J, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PM, Walker NJ, Paules RS. 2019. Screening for developmental neurotoxicity at the National Toxicology Program: the future is here [Abstract No. 1367]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):88.

Bell SM, Burgoon LD, Phillips J, Ceger P, Chang X, Karmaus AL, Allen DG, Casey WM, Kleinstreuer NC. 2018. ICE tools for aligning assay endpoints to adverse outcome pathways [Abstract No. 2534]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):373.

Bell S, Ceger P, Allen D, Kleinstreuer N. 2018. Open, accessible toxicity testing data for chemical evaluation. Presented at OpenTox USA 2018; Research Triangle Park, NC; 11-12 July 2018.

Bell S, Choksi N, Ceger P, Daniel A, Karmaus A, Abedini J, Allen D, Casey W, Kleinstreuer N. 2019. Good decisions require good data: creating curated and structured resources for toxicology. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Karmaus AL, Mansouri K, McAfee E, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2019. The Integrated Chemical Environment: tools and data to support toxicity assessments [Abstract No. 1747]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):175.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2018. User-friendly toxicology tools from ICE Workflows. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2018. User-friendly toxicology tools from ICE Workflows. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Bell S, Phillips J, Chang X, Rai R, Karmaus A, Hermes F, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2019. Facilitating chemical evaluation and data exploration with the Integrated Chemical Environment. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Camacho L, Porter-Gill P, Swift S, Abdel-Rahman A, Welch C, Fitzpatrick S. 2018. Effect of pH and gastro-intestinal conditions on the fibrinolytic activity of nattokinase and lumbrokinase in vitro [Abstract No. 2929]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):466.

Casey W. 2018. Future strategies for developmental and reproductive toxicity testing. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Ceger P, Bell S, Choksi N, Hamm J, Daniel A, Allen D, Kleinstreuer N. 2019. Application of a controlled vocabulary to curated databases of in vivo developmental toxicity data [Abstract No. P68]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Ceger P, Hamm J, Allen D, Maull EA, Casey W. 2018. Zebrafish ontologies for toxicological screening. Presented at OpenTox USA 2018; Research Triangle Park, NC; 11-12 July 2018.

Ceger P, Hamm J, Allen D, Maull EA, Casey W. 2018. Zebrafish ontologies for toxicological screening. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen DG, Casey WM, Kleinstreuer NC. 2018. An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen DG, Casey WM, Kleinstreuer NC. 2018. An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Chang X, Mansouri K, Hermes F, Phillips J, Bell SM, Allen DG, Casey WM, Kleinstreuer NC. An open-source, generalized workflow for IVIVE analysis [Abstract No. 3138]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):480.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SN, van Cott A, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D. 2019. Defined approach for detection of eye irritants and corrosives for pesticide formulations [Abstract No. 3514]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(S1):138.

Choksi N, Daniel A, Lebrun S, Nguyen M, DeGeorge G, Willoughby JA, Casey W, Allen D. 2018. Performance of the OptiSafe ocular irritation assay in a three-laboratory validation study [Abstract No. 3160]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):522.

Dolan L, Flannery B, Fitzpatrick S. 2019. Systematic review on the effects of a 0.5 µg/dL blood lead level in children and pregnant women [Abstract No. 2342]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):319.

Emond C, Ruiz P, Mumtaz M. 2018. A biological modeling approach for a malathion and parathion mixture utilizing Tox21 data [Abstract No. 3287]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):552.

Farcas M, Stefaniak A, Knepp A, Bowers L, Jackson S, Mandler W, Stueckle T, Friend S, Qi C, Hammond D, Thomas T, Matheson J, Qian Y. 2019. Physicochemical characterization and in vitro toxicity of emissions from a 3D printer [Abstract No. 3069]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):464.

Ferguson SS, Ramaiahgari SC, Saddler T, Auerbach S, Sipes N, Rice JR, Dunlap PE, Merrick B, Shah R, DeVito MJ, Paules RS. 2018. Total number of benchmark concentration from high-throughput transcriptomics and organotypic liver models as quantitative indicators of liver injury potential [Abstract No. 3153]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):520.

Fitzpatrick S. 2018. Predictive toxicology for regulatory decisions: implementing new approaches at FDA. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Fitzpatrick S. 2019. A view across the Atlantic: synopsis and opportunities [Abstract No. 1630]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):150.

Fransoza J, Craig E, Dobreniecki S, Perron M, Pope-Varsalona H, Houck K, Lowit A, Thomas R. 2018. Application of CompTox data to support chemical group identification of pesticides for cumulative risk assessment [Abstract No. 2122]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):272.

Goode J. 2018. Qualification of non-animal methods for biocompatibility assessment of medical devices: use of medical device development tools (MDDTs). Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Gordon J, Uhl R, Toman B, Elliot J, Petersen E. 2019. Increasing confidence in the EASA skin sensitization assay using a measurement science approach [Abstract No. 2425]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):339.

Griffiths JC, Edwards J, Fitzpatrick S, Galli CL, Hayes AW, Mahony C, Marsman DS, Oberlies NH, O’Keefe L, Roe AL, Walker NJ, Wilson CL. 2018. Development of a consensus approach for botanical safety evaluations [Abstract No. 1602]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):147.

Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K. 2018. Evaluating perturbation of in vitro steroidogenesis using a high-throughput H295R assay [Abstract No. 2124]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):273.

Hakkinen P. 2018. The re-envisioning of the National Library of Medicine's toxicology and environmental health resources. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Hamm J, Behl M, Ceger P, Haendel M, Marvel S, Maull E, Muriana A, Reif D, Tanguay R, Thessen A, Truong L, Vallant M, Walker N, Ryan K. 2019. The National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology: SEAZIT [Abstract No. P36]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Hamm J, Ceger P, Chang X, Maull E, Mahapatra D, Knuth M, Lingerfelt M, Ekins S, Xia M, Kullman SW. 2018. Evaluation of FXR-active chemicals identified from Tox21 screening [Abstract No. 2910]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):462.

Harrill A, Behl M, Choi T, Page L, Everett L, Balik-Meisner M, Porter D, Witt K, Paules R. 2018. Population variability in neurotoxicity outcomes modeled in vitro with diversity outbred neural progenitor cells [Abstract No. 2136]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):276.

Hilton GM, Odenkirchen E, Panger M, Waleko G, Lowit A, Clippinger AJ. 2019. Examination of the avian acute oral versus sub-acute dietary testing in ecological risk assessment [Abstract No. 1159]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):38.

Hsieh J, Lin J, Sedykh A, Parham F, Shapiro A, Sipes NS, Ryan K, Behl M, Paules RS, Auerbach SS. 2018. A non-parametric approach for selecting benchmark responses for in vitro or alternative animal model data [Abstract No. 2495]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):364.

Hung P. 2019. Electronic nicotine delivery systems in context: the US FDA perspective [Abstract No. 2597]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):377.

Karmaus AL, Bell SM, Allen DG, Casey WM, Kleinstreuer NC. 2019. Adding context to Tox21/ToxCast data: linking in vitro assays to toxicity outcomes [Abstract No. 1745]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):175.

Karmaus A, Fitzpatrick J, Allen D, Patlewicz G, Kleinstreuer N, Casey W. 2018. Variability of LD50 values from rat oral acute toxicity studies: implications for alternative model development [Abstract No. 2354]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):329.

Karmaus A, Mansouri K, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. 2018. Collaboration to develop predictive models for acute oral systemic toxicity. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Kiros B, Mav D, Everett L, Shah R, Paules R, Scott A. 2018. Identifying and annotating hallmark genes relevant to toxicogenomics [Abstract No. 2103]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):268.

Kleinstreuer NC. 2019. Current and future opportunities for U.S. regulatory application of developmental toxicity NAMs [Abstract No. 3207]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):496.

Kleinstreuer NC. 2019. Derivation of a dataset for modeling acute oral toxicity and variability assessment of in vivo LD50 data [Abstract No. 2562]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Kleinstreuer NC. 2019. Federal agency activities to identify and implement alternatives [Abstract No. S27]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Kleinstreuer NC. 2019. IVIVE tools for risk assessment [Abstract No. 1018]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):5.

Kleinstreuer NC. 2019. The march toward big data in toxicology: striking a balance between machine learning and mechanistic modeling. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Lavrich KS, Ramaiahgari, DeVito MJ, Paules RS, Ferguson SS. 2019. What’s so special about 3D spheroid cultures? Exploration of best practices with human hepatocyte models over time in culture [Abstract No. 1080]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):18.

Lebrun SJ, Choksi N, Daniel A, Allen D, Casey W. 2019. Prevalidation of the OptiSafe ocular irritation assay for the detection of ocular corrosives [Abstract No. 2453]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):346.

Leonard J, Nelms M, Craig E, Dobreniecki S, Perron M, Pope-Varsalona H, Lowit A, Tan C. 2019. An integrated approach to evaluate common mechanisms of toxicity in pesticides to support cumulative risk assessment [Abstract No. 2762]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):415.

Lowit A. 2019. Regulatory progress on acute toxicity testing [Abstract No. 2561]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Lowit A. 2019. U.S. EPA initiative to implement alternatives to acute systemic toxicity: an update [Abstract No. 2508]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):359.

Mansouri K. 2018. Computational approaches to human-relevant endocrine disruption screening. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Mansouri K. 2019. International collaboration to build predictive models for acute oral toxicity [Abstract No. 2563]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Mansouri K, Cariello N, Korotcov A, Tkachenko V, Casey W, Kleinstreuer N, Allen D, Grulke C, Williams AJ. 2018. Open source QSAR Models for pKa prediction using multiple machine learning approaches. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. 2019. Collaborative modeling project for predicting acute oral toxicity. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson RS. 2018. Virtual screening of chemicals for estrogen and androgen activities [Abstract No. 2524]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):371.

Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson RS. 2018. Virtual screening of chemicals for estrogen and androgen activities. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Martin WK, Padilla S, Kim Y, Hays MD, Hunter DL, Hazari MS, DeMarini DM, Gilmour MI, Farraj AK. 2019. What’s so special about 3D spheroid cultures? Exploration of best practices with human hepatocyte models over time in culture [Abstract No. 1108]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):25.

Martin WK, Tennant AH, Conolly, RB, Stevens JS, DeMarini DM, Gilmour MI, Cascio WE, Hays ME, Martin BL, Thompson LC, Hazari MS, Padilla S, Farraj AK. 2018. An automated heart rate detection platform in wildtype zebrafish for cardiotoxicity screening of fine particulate matter air pollution [Abstract No. 1167]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):39.

Mattes WB, Regev A, Church RJ, Watkins PB, Avigan M, Mendrick D, Greenhaw JJ, Shi Q. 2019. Transient alanine aminotransferase increases following acetaminophen treatment in rats [Abstract No. 1470]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):112.

Mendrick D. 2018. Importance of translation from in vitro testing to approved products and treatments [Abstract No. 1720]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):176.

Mendrick D. 2018. Microphysiological systems and data models for children's health issues: applications for organ specific assessments. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Merrick A, Phadke D, Shah R, Pelch K, Auerbach S, Paules R, DeVito M, Waalkes M, Tokar E. 2019. Oncogenic KRAS occurs after prolonged in vitro arsenite exposure of human prostate epithelial cells [Abstract No. 2322]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):314.

Mumtaz M, Johnson M, Genderen E, Ottinger M, Beasley A, Furlong E, Brix K, Schlekat T, Backhaus T. 2018. Report of the 2017 Society of Environmental Toxicology and Chemistry (SETAC) Conference on Risk Assessment of Chemical Mixtures [Abstract No. 2087b]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):264.

Mumtaz M, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus AL, Matheson J, Ruiz P, Scarano L, Kleinstreuer NC, Patlewicz G. 2019. Exploring current read-across applications and needs among U.S. federal agencies [Abstract No. 2485]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):354.

Niemeijer M, Huppelschoten S, Baze A, Parmentier C, Paules RS, Richert L, van de Water B. 2019. Transcriptomic profiling of the inter-individual variability of chemical-induced cellular stress response activation using a large panel of primary human hepatocyte donors [Abstract No. 1287]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):69.

Ono A, Watanabe S, Sugawara t, Wakabayashi K, Tahara Y, Horle N, Fujimoto K, Kusakari K, Kurokawa Y, Sozu T, Nakayama T, Kusao T, Kawakami T, Kojima K, Kojima H, Richmond J, Kleinstreuer N, Bae-Hwa K, Yamamoto Y, Fujita M, Kasahara T. 2018. A multi-centre validation study of amino acid derivative reactivity assay (ADRA): a novel in chemico alternative test method for skin sensitization [Abstract No. 3070]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):500.

Padilla S, Waalkes M, Hunter DL, Hedge J, Jarema K. 2019. Assessing the developmental toxicity and developmental neurotoxicity of 26 organophosphorus pesticides using a zebrafish (Danio rerio) larval assay [Abstract No. 1379]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):91.

Palmer JA, Burrier RE, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer NC. 2018. A human pluripotent stem cell-based assay accurately predicts the developmental toxicity potency for a series of valproate analogues. Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Palmer J, Smith A, Burrier R, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer N. 2018. Valproate analogue developmental toxicity potency in a human pluripotent stem cell-based assay is concordant with in vivo potency [Abstract No. 3262]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):546.

Perkins E, Burgoon L, Garcia-Reyero N, Gearhart JM, McAtee M, Ott D, Pangburn H, Reinke E, Stolle L. 2019. Development of a joint DOD roadmap to promote the use of new approach methodologies in rapid chemical hazard assessment [Abstract No. 2795]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):423.

Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. 2019. Assessment of neurotoxic potential of 90 blinded compounds using zebrafish embryos [Abstract No. 1376]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):90.

Ramaiahgari SC, Auerbach SS, Saddler TO, DeVito MJ, Merrick AB, Paules RS, Ferguson SS. 2019. 3D hepatocyte spheroid models in high-throughput transcriptomics and benchmark concentration analysis for predictive liver toxicology screening [Abstract No. 2622]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):382.

Ramaiahgari SC, Saddler T, Waidyanatha S, Dixon D, Sipes NS, Merrick AB, Rice JR, Dunlap PE, DeVito MJ, Paules RS, Auerbach SS, Ferguson SS. 2018. Functional characterization of human and rat 3D hepatocyte models and application of high-throughput transcriptomics (S1500+) in toxicology screening [Abstract No. 3154]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):521.

Reinke EN, Adams VH, Eck WS. 2018. Prediction of skin sensitization potential in compounds of military interest by in vitro methodologies [Abstract No. 3146]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):519.

Ruiz P, Emond C, Mumtaz M. 2019. Gaining insights to molecular mechanisms of combined air pollutants exposures using PBPK models and systems biology approaches [Abstract No. 1827]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):194.

Ryan KR, Hsieh JH, Parham F, Shapiro A, Sipes N, Collins B, Maull E, Paules RS, Walker N, Behl M. 2018. Strategies and advancements to evaluate developmental neurotoxicity at the National Toxicology Program. Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Schaefer H, Fitzpatrick S, Flannery B. 2019. Chemical contaminants in children's foods: a review of recent literature [Abstract No. 2640]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):386.

Sedykh A, Choksi N, Allen D, Kleinstreuer N, Casey W, Shah RR. 2019. Mixture-based modeling of chemical ocular toxicity based on US EPA hazard categories [Abstract No. 3401]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(S1):60.

Shah I, Harrill J, Setzer RW, Haggard D, Karmaus A, Martin MT, Thomas RS. 2018. Predicting chemical mechanisms-of-action using high-throughput transcriptomic data [Abstract No. 2507]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):367.

Sipes N. 2019. Parsimonious selection of cell lines to reproduce phenotypic variability [Abstract No. 3223]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):499.

Sipes NS, Huang R, Shockley K, Martin MT, Shapiro A, Addington J, Auerbach S, Paules R, Judson R, Houck K, Hong H, Hsieh J. 2018. Confidence in fitting and hitting concentration-response data: Tox21 10K library pipeline comparison [Abstract No. 2508]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):367.

Strickland J, Gordon J, Hettick J, Law B, Petersen EJ, Solomotis N, Truax J, Uhl R, Yourick J, Allen D, Kleinstreuer N. 2018. Phase 1 validation of the electrophilic allergen screening assay. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Tao J, Kelgwin T, Lowit A. 2018. Reduce animal use for acute toxicity in U.S. EPA pesticide programs [Abstract No. 1639]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):156.

van de Water B, Niemeiger M, Huppelschoten S, den Hollander W, Paules R, Richert L. 2018. High-throughput transcriptomics to dissect the inter-individual variability of the unfolded protein response activation using a large panel of primary human hepatocytes [Abstract No. 1313]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):75.

Wynder J, Ovesen J, Maier A, Judson R, Kleinstreuer N, Krishnan M. 2018. Evaluating the applicability of read-across tools and high-throughput screening data for food relevant chemicals [Abstract No. 1613]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):150.