U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.


ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Articles in the NIEHS Environmental Factor newsletter

Kelly C. March 2019. MOU aims to improve cardiovascular safety of pharmaceuticals. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/3/science-highlights/cardiovascular/index.htm

Scruggs S. June 2019. The National Toxicology Program converges on cancer. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/6/science-highlights/cancer/index.htm

Sprankle C. February 2018. Roadmap to guide progress toward replacing animal use. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/2/science-highlights/roadmap/index.htm

Sprankle C. May 2018. Advancing computer models that predict toxicity. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/5/science-highlights/toxicity/index.htm

Sprankle C. June 2018. NTP promotes international use of nonanimal test methods. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/6/science-highlights/nonanimal/index.htm

Sprankle C. July 2018. Plan to reduce animal testing showcased at public forum [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/7/science-highlights/animal_testing/index.htm

Sprankle C. September 2018. Replacing animal testing – progress and challenges [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/9/science-highlights/nonanimal/index.htm

Sprankle C. October 2018. Regulators play key roles in replacing animals in tox testing [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/10/science-highlights/toxicity_testing/index.htm

Sprankle C. December 2018. Building confidence in new scientific methods challenges researchers [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/12/science-highlights/new-methods/index.htm

Sprankle C. February 2019. SOT honors computational, nonanimal testing pioneer [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/2/awards-recognition/sot-awards/index.htm

Sprankle C. June 2019. New website tool helps replace animal tests [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/6/science-highlights/ice/index.htm

Sprankle C. July 2019. Fruitful partnerships advance alternatives to animal testing [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/7/science-highlights/fruitful/index.htm

Sprankle C. November 2019. Experts debate challenges of tissue chips, machine learning [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/11/science-highlights/animal-testing/index.htm

Weaver J. July 2018. Web resources could assist chemical management [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/7/science-highlights/chemical_risk/index.htm