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ICCVAM Biennial Report 2018-2019

ICCVAM Biennial Report 2018-2019
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NICEATM and ICCVAM Publications, 2018-2019

NICEATM and ICCVAM Reports

ICCVAM. 2018. A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 09 March 2020]. Available: https://ntp.niehs.nih.gov/go/iccvam-rdmp. https://dx.doi.org/10.22427/NTP-ICCVAM-ROADMAP2018.

ICCVAM. 2018. Biennial Progress Report 2016-2017: Interagency Coordinating Committee on the Validation of Alternative Methods [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences [cited 09 March 2020]. Available: https://ntp.niehs.nih.gov/iccvamreport/2017/index.html.

Federal Register Notices

All Federal Register notices issued by NICEATM can be found on the NTP website at http://ntp.niehs.nih.gov/go/frn.

NIEHS. 2018. ICCVAM Communities of Practice Webinar on Machine Learning in Toxicology: Fundamentals of Application and Interpretation; notice of public webinar; registration information. Federal Register. 83(5):823-824.

NIEHS. 2018. A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States; availability of report. Federal Register. 83(35):7487.

NIEHS. 2018. Predictive Models for Acute Oral Systemic Toxicity; notice of meeting; registration information. Federal Register. 83(36):7750-7751.

NIEHS. 2018. ICCVAM notice of public meeting; request for public input. Federal Register. 83(67):14867-14869.

NIEHS. 2018. Request for data and information on technologies used for identifying potential developmental toxicants. Federal Register. 83(88):20082.

NIEHS. 2018. Request for data and information on technologies used to detect and measure botulinum neurotoxin. Federal Register. 83(114):27622-27623.

NIEHS. 2018. ICCVAM Biennial Progress Report: 2016-2017; availability of report. Federal Register. 83(152):38717-38718.

NIEHS. 2019. ICCVAM notice of public meeting; request for public input. Federal Register. 84(71):14953-14954.

NIEHS. 2019. ICCVAM Communities of Practice Webinar on Use of Animal-free Affinity Reagents. Federal Register. 84(228):61567-61568.

Journal Articles

Alberga D, Trisciuzzi D, Mansouri K, Mangiatordi GF, Nicolotti O. 2019. Prediction of acute oral systemic toxicity using a multifingerprint similarity approach. Toxicol Sci 167(2):484-495. https://doi.org/10.1093/toxsci/kfy255.

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2018. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol In Vitro 47:213-227. https://doi.org/10.1016/j.tiv.2017.11.016.

Bernasconi C, Pelkonen O, Andersson TB, Strickland J, Wilk-Zasadna I, Asturiol D, Cole T, Liska R, Worth A, Müller-Vieira U, Richert L, Chesne C, Coecke S. 2019. Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study. Toxicol In Vitro 60:212-228. https://doi.org/10.1016/j.tiv.2019.05.019.

Borrel A, Kleinstreuer NC, Fourches D. 2018. Exploring drug space with ChemMaps.com. Bioinformatics 34(21):3773-3775. https://doi.org/10.1093/bioinformatics/bty412.

Browne P, Kleinstreuer NC, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS, Judson RJ, Casey W. 2018. Development of a curated Hershberger database. Reprod Toxicol 81:259-271. https://doi.org/10.1016/j.reprotox.2018.08.016.

Burgdorf T, Peirsma AH, Landsiedel R, Clewell R, Kleinstreuer N, Oelgeschlager M, Desprez B, Kienhuis A, Bos P, de Vries R, de Wit L, Seidle T, Scheel J, Schonfelder G, van Benthem J, Vinggard AM, Eskes C, Ezendam J. 2019. Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - evolution versus revolution. Toxicol In Vitro 59:1-11. https://doi.org/10.1016/j.tiv.2019.03.039.

Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Regimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V. 2018. Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods. Arch Toxicol 92:611-617. https://doi.org/10.1007/s00204-017-2097-4.

Casey WM, Chang X, Allen DG, Ceger P, Choksi NY, Hsieh J-H, Wetmore BA, Ferguson SS, DeVito MJ, Sprankle CS, Kleinstreuer NC. 2018. Evaluation and optimization of pharmacokinetic models for in vitro to in vivo extrapolation of estrogenic activity for environmental chemicals. Environ Health Perspect 126(9):97001. https://doi.org/10.1289/EHP1655.

Casey W, Lowit A. 2019. USA: ICCVAM and NICEATM. In: Balls M, Combes R, Worth A. 2019. The History of Alternative Test Methods in Toxicology. London: Academic Press. https://doi.org/10.1016/B978-0-12-813697-3.00015-9.

Chesnut M, Yamada T, Adams T, Knight D, Kleinstreuer N, Kass G, Luechtefeld T, Hartung T. 2018. Regulatory acceptance of read-across. ALTEX 35(3):413-419. https://doi.org/10.14573/altex.1805081.

Choksi NY, Truax J, Layton A, Matheson J, Mattie D, Varney T, Tao J, Yozzo K, McDougal AJ, Merrill J, Lowther D, Barroso J, Linke B, Casey W, Allen D. 2019. United States regulatory requirements for skin and eye irritation testing. Cutan Ocular Toxicol 38(2):141-155. PMID 30418044. https://doi.org/10.1080/15569527.2018.1540494.

Clippinger AJ, Allen D, Behrsing H,  BéruBé KA, Bolger MB, Casey W, DeLorme M, Gaça M, Gehen SC, Glover K, Hayden P, Hinderliter P, Hotchkiss JA, Iskandar A, Keyser B, Luettich K, Ma-Hock L, Maione AG, Makena P, Melbourne J, Milchak L, Ng SP, Paini A, Page K, Patlewicz G, Prieto P, Raabe H, Reinke EN, Roper C, Rose J, Sharma M, Spoo W, Thorne PS, Wilson DM, Jarabek AM. 2018. Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro 52:131-145. https://doi.org/10.1016/j.tiv.2018.06.009Honorable Mention winner, Best Paper of 2018, Society of Toxicology Biological Modeling Specialty Section.

Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro 48:53-70. https://doi.org/10.1016/j.tiv.2017.12.011.

Corton JC, Kleinstreuer NC, Judson RS. 2019. Identification of potential endocrine disrupting chemicals using gene expression biomarkers. Toxicol Appl Pharmacol 380:114683. https://doi.org/10.1016/j.taap.2019.114683.

Daniel AB, Strickland J, Allen D, Casati S, Zuang V, Barroso J, Whelan M, Regimbald-Krnel MJ, Kojima H, Nishikawa A, Park HK, Lee JK, Kim TS, Delgado I, Rios L, Yang Y, Wang G, Kleinstreuer N. 2018. International regulatory requirements for skin sensitization testing. Regul Toxicol Pharmacol 95:52-65. https://doi.org/10.1016/j.yrtph.2018.03.003.

Fujita M, Yamamoto Y, Watanabe S, Sugawara T, Wakabayashi K, Tahara Y, Horie N, Fujimoto K, Kusakari K, Kurokawa Y, Kawakami T, Kojima K, Sozu T, Nakayama T, Kusao T, Richmond J, Kleinstreuer N, Kim B-H, Kojima H, Kasahara T, Ono T. 2019. The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories. J Appl Toxicol 39(11)1492-1505. https://doi.org/10.1002/jat.3834.

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. 2019. Chronic inflammation in the etiology of disease across the life span. Nat Med 25(12):1822-1832. https://doi.org/10.1038/s41591-019-0675-0.

Gadaleta D, Vukovic K, Toma C, Lavado GJ, Karmaus AL, Mansouri K, Kleinstreuer NC, Benfenati E, Roncaglioni A. 2019. SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data. J Cheminfor 11, 58. https://doi.org/10.1186/s13321-019-0383-2.

Haggard D, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul-Friedman K. 2018. High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis. Toxicol Sci 162(2): 509-534. https://doi.org/10.1093/toxsci/kfx274.

Hamm JT, Ceger P, Allen D, Stout M, Maull EA, Baker G, Zmaroski A, Padilla S, Perkins E, Planchart A, Stedman D, Tal T, Tanguay RL, Volz DC, Wilbanks MS, Walker NJ. 2019. Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX 36(1):103-120. https://doi.org/10.14573/altex.1804162.

Huang R, Xia M, Sakamuru S, Zhao J, Lynch C, Zhao T, Zhu H, Austin CA, Simeonov A. 2018. Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles. Sci Rep 8, 3783. https://doi.org/10.1038/s41598-018-22046-w.

Harrill J, Shah I, Setzer RW, Haggard D, Auerbach S, Judson R, Thomas RS. 2019. Considerations for strategic use of high-throughput transcriptomics chemical screening data in regulatory decisions. Curr Opin Toxicol 15:64-75. https://doi.org/10.1016/j.cotox.2019.05.004.

Hoffman S, Kleinstreuer NC, Alepee N, Allen D, Api AM, Ashikaga T, Clouet E, Cluzel M, Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kuhnl J, Lalko JF, Martinozzi-Teisslier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D. 2018. Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database. Crit Rev Toxicol 48(5):344-358. https://doi.org/10.1080/10408444.2018.1429385.

Huang R, Grishagin I, Wang Y, Zhao T, Greene J, Obenauer JC, Ngan D, Nguyen DT, Guha R, Jadhav A, Southall N, Simeonov A, Austin CP. 2019. The NCATS Bioplanet – an integrated platform for exploring the universe of cellular signaling pathways for toxicology, systems biology, and chemical genomics. Front Pharmacol. DOI: https://doi.org/10.3389/fphar.2019.00445.

Judson RS, Paul Friedman K, Houck K, Mansouri K, Browne P, Kleinstreuer NC. 2018. New approach methods for testing chemicals for endocrine disruption potential. Curr Opin Toxicol 9:40-47. https://doi.org/10.1016/j.cotox.2018.10.002.

Judson RS, Thomas RS, Baker N, Simha A, Howey XM, Marable C, Kleinstruer NC, Houck KA. 2018. Workflow for defining reference chemicals for assessing performance of in vitro assays. ALTEX 36(2):261-276. >https://doi.org/10.14573/altex.1809281.

Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. 2018. Evaluation of androgen assay results using a curated Hershberger database. Reprod Toxicol 81:272-280. https://doi.org/10.1016/j.reprotox.2018.08.017.

Kleinstreuer NC, Hoffman S, Alepee N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Gobel C, Kern PS, Klaric M, Kuhnl J, Martinozzi-Teisslier S, Mewes K, Miyazawa M, Strickland J, van Vliet E, Zang Q, Petersohn D. 2018. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches. Crit Rev Toxicol 48(5);359-374. https://doi.org/10.1080/10408444.2018.1429386Winner, Best Paper of 2018, Society of Toxicology Risk Assessment Specialty Section.

Kleinstreuer NC, Karmaus A, Mansouri K, Allen DG, Fitzpatrick JM, Patlewicz G. 2018. Predictive models for acute oral systemic toxicity: a workshop to bridge the gap from research to regulation. Computational Toxicol 8:21-24. https://doi.org/10.1016/j.comtox.2018.08.002.

Kojima H, Yamaguchi H, Sozu T, Kleinstreuer N, Chae-Hyung L, Chen W, Watanabe M, Fukuda T, Yamashita K, Takezawa K. 2019. Multi-laboratory validation study of the Vitrigel-Eye Irritancy Test Method as an alternative to in vivo eye irritation testing. Altern Lab Anim 47(3-4):140-157. https://doi.org/10.1177/0261192919886665.

Kolanjiyil AV, Kleinstreuer C, Kleinstreuer NC, Pham W, Sadikot RT. 2019. Mice-to-men comparison of inhaled drug-aerosol deposition and clearance. Respir Physiol and Neurobiol 260:82-94. https://doi.org/10.1016/j.resp.2018.11.003.

Kornberg TG, Stueckle TA, Coyle J, Derk R, Demokritou P, Rojanasakul Y, Rojanasakul LW. 2019. Iron oxide nanoparticle-induced neoplastic-like cell transformation in vitro is reduced with a protective amorphous silica coating. Chem Res Toxicol 32(12):2382-2397. https://doi.org/10.1021/acs.chemrestox.9b00118.

Li S, Zhao J, Huang R, Santillo MF, Xia M. 2019. Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorus pesticides. Toxicol In Vitro 56:93-100. https://doi.org/10.1016/j.tiv.2019.01.002.

Linakis MW, Sayre RR, Pearce RG, Sfier MA, Sipes NS, Pangburn HA, Gearhart JM, Wambaugh JF. 2020. Development and evaluation of a high throughput inhalation model for organic chemicals [in press]. J Exposure Science Environ Epidemiology. https://doi.org/10.1038/s41370-020-0238-y.

Mahony C, Currie R, Daston G, Kleinstreuer N, van de Water B. 2018. Highlight report: 'Big data in the 3Rs: outlook and recommendations', a roundtable summary. Arch Toxicol 92:1015-1020. https://doi.org/10.1007/s00204-017-2145-0.

Manganelli S, Roncaglioni A, Mansouri K, Judson RS, Benfenati E, Manganaro A, Ruiz P. 2019. Development, validation and integration of in silico models to identify androgen active chemicals. Chemosphere 220:204-215. https://doi.org/10.1016/j.chemosphere.2018.12.131.

Mansouri K, Cariello NF, Korotcov A, Tkachenko V, Grulke CM, Sprankle CS, Allen D, Casey WM, Kleinstreuer NC, Williams AJ. 2019. Open-source QSAR models for pKa prediction using multiple machine learning approaches. J Cheminfor 11:60. https://doi.org/10.1186/s13321-019-0384-1.

Mansouri K, Grulke CM, Judson RS, Williams AJ. 2018. OPERA models for predicting physicochemical properties and environmental fate endpoints. J Cheminform 10(1):10. https://doi.org/10.1186/s13321-018-0263-1.

Marshall LJ, Austin CP, Casey W, Fitzpatrick SC, Willett C. 2018. Recommendations toward a human pathway-based approach to disease research. Drug Discov Today 23(11):1824-1832. https://doi.org/10.1016/j.drudis.2018.05.038.

Myatt GJ, Ahlberg E, Akahori Y, Allen D, Amberg A, Anger LT, Aptula A, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Burden N, Cammerer Z, Cronin MTD, Cross KP, Custer L, Dettwiler M, Dobo K, Ford KA, Fortin MC, Gad-McDonald SE, Gellatly N, Gervais V, Glover KP, Glowienke S, Van Gompel J, Gutsell S, Hardy B, Harvey JS, Hillegass J, Honma M, Hsieh J-H, Hsu C-W, Hughes K, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kim MT, Kruhlak NL, Kulkami SA, Kummerer K, Leavitt P, Majer B, Masten S, Miller S, Moser J, Mumtaz M, Muster W, Neilson L, Oprea TI, Patlewicz G, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz A-N, Ruiz P, Schilter B, Serafimova R, Simpson W, Stavitskaya L, Stidl R, Suarez-Rodriguez D, Szabo DT, Teasdale A, Trejo-Martin A, Valentin J-P, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Hasselgren C. 2018. In silico toxicology protocols. Regul Toxicol Pharmacol 96:1-17. https://doi.org/10.1016/j.yrtph.2018.04.014.

Patlewicz G, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus A, Matheson J, Mumtaz M, Richarz AN, Ruiz P, Scarano L, Yamada T, Kleinstreuer N. 2019. Exploring current read-across applications and needs among selected U.S. federal agencies. Regul Toxicol Pharmacol 106:197-209. https://doi.org/10.1016/j.yrtph.2019.05.011.

Poston R, Hill R, Allen C, Casey W, Gatewood D, Levis R, Mallet L, Smith D, Srivinas G, Stirling C, Allen D. 2019. Achieving scientific and regulatory success in implementing non-animal approaches to human and veterinary rabies vaccine testing: A NICEATM and IABS workshop report. Biologicals 60:8-14. https://doi.org/10.1016/j.biologicals.2019.06.005.

Prior H, Casey W, Kimber I, Whelan M, Sewell F. 2019. Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals. Regul Toxicol Pharmacol 102:30-33. https://doi.org/10.1016/j.yrtph.2018.12.008.

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS. 2019. The power of resolution: contextualized understanding of biological responses to liver injury chemicals using high-throughput transcriptomics and benchmark concentration modeling. Toxicol Sci 169(2):553-566. https://doi.org/10.1093/toxsci/kfz065.

Rooney JP, Chorley B, Kleinstreuer N, Corton JC. 2018. Identification of androgen receptor modulators in a prostate cancer cell line microarray compendium. Toxicol Sci 166(1):146-162. https://doi.org/10.1093/toxsci/kfy187.

Russo DP, Strickland J, Karmaus AL, Wang W, Shende S, Hartung T, Aleksunes LM, Zhu H. 2019. Nonanimal models for acute toxicity evaluations: applying data-driven profiling and read-across. Environ Health Perspect 127(4):47001. https://doi.org/10.1289/EHP3614.

Saili KS, Franzosa JA, Baker NC, Ellis-Hutchings RG, Settivari RS, Carney EW, Spencer R, Zurlinden TJ, Kleinstreuer NC, Li S, Xia M, Knudsen TB. 2019. Systems modeling of developmental vascular toxicology. Curr Opin Toxicol 15:55-63. https://doi.org/10.1016/j.cotox.2019.04.004.

Smirnova L, Kleinstreuer N, Corvi R, Levchenko A, Fitzpatrick SC, Hartung T. 2018. 3S - Systematic, systemic, and systems biology and toxicology. ALTEX 35(2):139-162. https://doi.org/10.14573/altex.1804051.

Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schonfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, K Shiota, Chahoud. 2019. Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol 89:124-129. https://doi.org/10.1016/j.reprotox.2019.07.003.

Strickland J, Clippinger AJ, Brown J, Allen D, Jacobs A, Matheson J, Lowit A, Reinke EN, Johnson MS, Quinn MJ. 2018. Status of acute toxicity testing requirements and data uses by U.S. regulatory agencies. Reg Toxicol Pharmacol 94:183-196. https://doi.org/10.1016/j.yrtph.2018.01.022.

Strickland J, Daniel AB, Allen D, Aguila C, Ahir S, Bancos S, Craig E, Germolec D, Ghosh C, Hudson NL, Jacobs A, Lehmann DM, Matheson J, Reinke EN, Sadrieh N, Vukmanovic S, Kleinstreuer N. 2019. Skin sensitization testing needs and data uses by U.S. regulatory and research agencies. Arch Toxicol 92(2):273-291. https://doi.org/10.1007/s00204-018-2341-6.

Strickland J, Paris MW, Allen D, Casey W. 2019. Approaches to reducing animal use for acute toxicity testing: retrospective analyses of pesticide data. In: Kojima H, Seidle T, Spielmann H. (eds), Alternatives to Animal Testing. Springer, Singapore. https://doi.org/10.1007/978-981-13-2447-5.

Thomas RS, Paules RS, Simeonov A, Fitzpatrick SC, Crofton KM, Casey WM, Mendrick DL. 2018. The US federal Tox21 program: a strategic and operational plan for continued leadership. ALTEX 35(2):163-168. https://doi.org/10.14573/altex.1803011.

Wei Z, Sakamuru S, Zhang L, Zhao J, Huang R, Kleinstreuer NC, Chen Y, Shu Y, Knudsen TB, Xia M. 2019. Identification and profiling of environmental chemicals that inhibit the TGFβ/SMAD signaling pathway. Chem Res Toxicol 32(12):2433-2444. https://doi.org/10.1021/acs.chemrestox.9b00228.

Abstracts

Allen D, Choksi N, Gehen S, Casey W, Clippinger A. 2018. Public-private partnerships to advance in vitro eye irritation testing methods and approaches. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Allen DG, Clippinger A, Morefield S, Casey WM, Ghosh C, Goode J, Brown J. 2019. Using the monocyte activation test for medical devices [Abstract No. 2469]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):350.

Anyangwe N, Fitzpatrick S, Flannery B, Mattia A, Schaefer H, Tyler T, Whiteside C. 2019. Use of dog studies in U.S. FDA’s safety assessments for food additives and color additives [Abstract No. 2781]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):419.

Balik-Meisner M, Phadke D, Mav D, Everett L, Shah R, Merrick BA, Paules R. 2019. Development of a zebrafish S1500+ sentinel gene set for high-throughput transcriptomics [Abstract No. 3178]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):490.

Beekhuijzen M, Kleinstreuer NC. 2018. Teratology Society and European Teratology Society exchange lecture: are we ready for alternative testing? Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Behl M, Ryan K, Hsieh J, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PM, Walker NJ, Paules RS. 2019. Screening for developmental neurotoxicity at the National Toxicology Program: the future is here [Abstract No. 1367]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):88.

Bell SM, Burgoon LD, Phillips J, Ceger P, Chang X, Karmaus AL, Allen DG, Casey WM, Kleinstreuer NC. 2018. ICE tools for aligning assay endpoints to adverse outcome pathways [Abstract No. 2534]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):373.

Bell S, Ceger P, Allen D, Kleinstreuer N. 2018. Open, accessible toxicity testing data for chemical evaluation. Presented at OpenTox USA 2018; Research Triangle Park, NC; 11-12 July 2018.

Bell S, Choksi N, Ceger P, Daniel A, Karmaus A, Abedini J, Allen D, Casey W, Kleinstreuer N. 2019. Good decisions require good data: creating curated and structured resources for toxicology. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Karmaus AL, Mansouri K, McAfee E, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2019. The Integrated Chemical Environment: tools and data to support toxicity assessments [Abstract No. 1747]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):175.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2018. User-friendly toxicology tools from ICE Workflows. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Bell SM, Phillips J, Cariello N, Ceger P, Chang X, Hermes F, Mansouri K, Rai R, Allen DG, Casey WM, Kleinstreuer NC. 2018. User-friendly toxicology tools from ICE Workflows. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Bell S, Phillips J, Chang X, Rai R, Karmaus A, Hermes F, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2019. Facilitating chemical evaluation and data exploration with the Integrated Chemical Environment. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Camacho L, Porter-Gill P, Swift S, Abdel-Rahman A, Welch C, Fitzpatrick S. 2018. Effect of pH and gastro-intestinal conditions on the fibrinolytic activity of nattokinase and lumbrokinase in vitro [Abstract No. 2929]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):466.

Casey W. 2018. Future strategies for developmental and reproductive toxicity testing. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Ceger P, Bell S, Choksi N, Hamm J, Daniel A, Allen D, Kleinstreuer N. 2019. Application of a controlled vocabulary to curated databases of in vivo developmental toxicity data [Abstract No. P68]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Ceger P, Hamm J, Allen D, Maull EA, Casey W. 2018. Zebrafish ontologies for toxicological screening. Presented at OpenTox USA 2018; Research Triangle Park, NC; 11-12 July 2018.

Ceger P, Hamm J, Allen D, Maull EA, Casey W. 2018. Zebrafish ontologies for toxicological screening. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen DG, Casey WM, Kleinstreuer NC. 2018. An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Chang X, Bell S, Rai R, Phillips J, Mansouri K, Allen DG, Casey WM, Kleinstreuer NC. 2018. An open-source IVIVE workflow integrating in vitro data, QSAR models, and reverse dosimetry. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Chang X, Mansouri K, Hermes F, Phillips J, Bell SM, Allen DG, Casey WM, Kleinstreuer NC. An open-source, generalized workflow for IVIVE analysis [Abstract No. 3138]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):480.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Ng S, Kolle SN, van Cott A, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D. 2019. Defined approach for detection of eye irritants and corrosives for pesticide formulations [Abstract No. 3514]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(S1):138.

Choksi N, Daniel A, Lebrun S, Nguyen M, DeGeorge G, Willoughby JA, Casey W, Allen D. 2018. Performance of the OptiSafe ocular irritation assay in a three-laboratory validation study [Abstract No. 3160]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):522.

Dolan L, Flannery B, Fitzpatrick S. 2019. Systematic review on the effects of a 0.5 µg/dL blood lead level in children and pregnant women [Abstract No. 2342]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):319.

Emond C, Ruiz P, Mumtaz M. 2018. A biological modeling approach for a malathion and parathion mixture utilizing Tox21 data [Abstract No. 3287]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):552.

Farcas M, Stefaniak A, Knepp A, Bowers L, Jackson S, Mandler W, Stueckle T, Friend S, Qi C, Hammond D, Thomas T, Matheson J, Qian Y. 2019. Physicochemical characterization and in vitro toxicity of emissions from a 3D printer [Abstract No. 3069]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):464.

Ferguson SS, Ramaiahgari SC, Saddler T, Auerbach S, Sipes N, Rice JR, Dunlap PE, Merrick B, Shah R, DeVito MJ, Paules RS. 2018. Total number of benchmark concentration from high-throughput transcriptomics and organotypic liver models as quantitative indicators of liver injury potential [Abstract No. 3153]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):520.

Fitzpatrick S. 2018. Predictive toxicology for regulatory decisions: implementing new approaches at FDA. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Fitzpatrick S. 2019. A view across the Atlantic: synopsis and opportunities [Abstract No. 1630]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):150.

Fransoza J, Craig E, Dobreniecki S, Perron M, Pope-Varsalona H, Houck K, Lowit A, Thomas R. 2018. Application of CompTox data to support chemical group identification of pesticides for cumulative risk assessment [Abstract No. 2122]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):272.

Goode J. 2018. Qualification of non-animal methods for biocompatibility assessment of medical devices: use of medical device development tools (MDDTs). Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Gordon J, Uhl R, Toman B, Elliot J, Petersen E. 2019. Increasing confidence in the EASA skin sensitization assay using a measurement science approach [Abstract No. 2425]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):339.

Griffiths JC, Edwards J, Fitzpatrick S, Galli CL, Hayes AW, Mahony C, Marsman DS, Oberlies NH, O’Keefe L, Roe AL, Walker NJ, Wilson CL. 2018. Development of a consensus approach for botanical safety evaluations [Abstract No. 1602]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):147.

Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K. 2018. Evaluating perturbation of in vitro steroidogenesis using a high-throughput H295R assay [Abstract No. 2124]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):273.

Hakkinen P. 2018. The re-envisioning of the National Library of Medicine's toxicology and environmental health resources. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Hamm J, Behl M, Ceger P, Haendel M, Marvel S, Maull E, Muriana A, Reif D, Tanguay R, Thessen A, Truong L, Vallant M, Walker N, Ryan K. 2019. The National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology: SEAZIT [Abstract No. P36]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Hamm J, Ceger P, Chang X, Maull E, Mahapatra D, Knuth M, Lingerfelt M, Ekins S, Xia M, Kullman SW. 2018. Evaluation of FXR-active chemicals identified from Tox21 screening [Abstract No. 2910]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):462.

Harrill A, Behl M, Choi T, Page L, Everett L, Balik-Meisner M, Porter D, Witt K, Paules R. 2018. Population variability in neurotoxicity outcomes modeled in vitro with diversity outbred neural progenitor cells [Abstract No. 2136]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):276.

Hilton GM, Odenkirchen E, Panger M, Waleko G, Lowit A, Clippinger AJ. 2019. Examination of the avian acute oral versus sub-acute dietary testing in ecological risk assessment [Abstract No. 1159]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):38.

Hsieh J, Lin J, Sedykh A, Parham F, Shapiro A, Sipes NS, Ryan K, Behl M, Paules RS, Auerbach SS. 2018. A non-parametric approach for selecting benchmark responses for in vitro or alternative animal model data [Abstract No. 2495]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):364.

Hung P. 2019. Electronic nicotine delivery systems in context: the US FDA perspective [Abstract No. 2597]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):377.

Karmaus AL, Bell SM, Allen DG, Casey WM, Kleinstreuer NC. 2019. Adding context to Tox21/ToxCast data: linking in vitro assays to toxicity outcomes [Abstract No. 1745]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):175.

Karmaus A, Fitzpatrick J, Allen D, Patlewicz G, Kleinstreuer N, Casey W. 2018. Variability of LD50 values from rat oral acute toxicity studies: implications for alternative model development [Abstract No. 2354]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):329.

Karmaus A, Mansouri K, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. 2018. Collaboration to develop predictive models for acute oral systemic toxicity. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Kiros B, Mav D, Everett L, Shah R, Paules R, Scott A. 2018. Identifying and annotating hallmark genes relevant to toxicogenomics [Abstract No. 2103]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):268.

Kleinstreuer NC. 2019. Current and future opportunities for U.S. regulatory application of developmental toxicity NAMs [Abstract No. 3207]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):496.

Kleinstreuer NC. 2019. Derivation of a dataset for modeling acute oral toxicity and variability assessment of in vivo LD50 data [Abstract No. 2562]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Kleinstreuer NC. 2019. Federal agency activities to identify and implement alternatives [Abstract No. S27]. Presented at the 59th Annual Meeting of the Teratology Society; San Diego; 22-26 June 2019.

Kleinstreuer NC. 2019. IVIVE tools for risk assessment [Abstract No. 1018]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):5.

Kleinstreuer NC. 2019. The march toward big data in toxicology: striking a balance between machine learning and mechanistic modeling. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Lavrich KS, Ramaiahgari, DeVito MJ, Paules RS, Ferguson SS. 2019. What’s so special about 3D spheroid cultures? Exploration of best practices with human hepatocyte models over time in culture [Abstract No. 1080]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):18.

Lebrun SJ, Choksi N, Daniel A, Allen D, Casey W. 2019. Prevalidation of the OptiSafe ocular irritation assay for the detection of ocular corrosives [Abstract No. 2453]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):346.

Leonard J, Nelms M, Craig E, Dobreniecki S, Perron M, Pope-Varsalona H, Lowit A, Tan C. 2019. An integrated approach to evaluate common mechanisms of toxicity in pesticides to support cumulative risk assessment [Abstract No. 2762]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):415.

Lowit A. 2019. Regulatory progress on acute toxicity testing [Abstract No. 2561]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Lowit A. 2019. U.S. EPA initiative to implement alternatives to acute systemic toxicity: an update [Abstract No. 2508]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):359.

Mansouri K. 2018. Computational approaches to human-relevant endocrine disruption screening. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Mansouri K. 2019. International collaboration to build predictive models for acute oral toxicity [Abstract No. 2563]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):369.

Mansouri K, Cariello N, Korotcov A, Tkachenko V, Casey W, Kleinstreuer N, Allen D, Grulke C, Williams AJ. 2018. Open source QSAR Models for pKa prediction using multiple machine learning approaches. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. 2019. Collaborative modeling project for predicting acute oral toxicity. Presented at the Eighth Annual Meeting of the American Society for Cellular and Computational Toxicology; Gaithersburg, MD; 24-26 September 2019.

Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson RS. 2018. Virtual screening of chemicals for estrogen and androgen activities [Abstract No. 2524]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):371.

Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson RS. 2018. Virtual screening of chemicals for estrogen and androgen activities. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Martin WK, Padilla S, Kim Y, Hays MD, Hunter DL, Hazari MS, DeMarini DM, Gilmour MI, Farraj AK. 2019. What’s so special about 3D spheroid cultures? Exploration of best practices with human hepatocyte models over time in culture [Abstract No. 1108]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):25.

Martin WK, Tennant AH, Conolly, RB, Stevens JS, DeMarini DM, Gilmour MI, Cascio WE, Hays ME, Martin BL, Thompson LC, Hazari MS, Padilla S, Farraj AK. 2018. An automated heart rate detection platform in wildtype zebrafish for cardiotoxicity screening of fine particulate matter air pollution [Abstract No. 1167]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):39.

Mattes WB, Regev A, Church RJ, Watkins PB, Avigan M, Mendrick D, Greenhaw JJ, Shi Q. 2019. Transient alanine aminotransferase increases following acetaminophen treatment in rats [Abstract No. 1470]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):112.

Mendrick D. 2018. Importance of translation from in vitro testing to approved products and treatments [Abstract No. 1720]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):176.

Mendrick D. 2018. Microphysiological systems and data models for children's health issues: applications for organ specific assessments. Presented at FutureTox IV – Progress to Maturity: Predictive Toxicology for Healthy Children; Arlington, VA; 14-16 November 2018.

Merrick A, Phadke D, Shah R, Pelch K, Auerbach S, Paules R, DeVito M, Waalkes M, Tokar E. 2019. Oncogenic KRAS occurs after prolonged in vitro arsenite exposure of human prostate epithelial cells [Abstract No. 2322]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):314.

Mumtaz M, Johnson M, Genderen E, Ottinger M, Beasley A, Furlong E, Brix K, Schlekat T, Backhaus T. 2018. Report of the 2017 Society of Environmental Toxicology and Chemistry (SETAC) Conference on Risk Assessment of Chemical Mixtures [Abstract No. 2087b]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):264.

Mumtaz M, Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, Hakkinen P, Howard AS, Karmaus AL, Matheson J, Ruiz P, Scarano L, Kleinstreuer NC, Patlewicz G. 2019. Exploring current read-across applications and needs among U.S. federal agencies [Abstract No. 2485]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):354.

Niemeijer M, Huppelschoten S, Baze A, Parmentier C, Paules RS, Richert L, van de Water B. 2019. Transcriptomic profiling of the inter-individual variability of chemical-induced cellular stress response activation using a large panel of primary human hepatocyte donors [Abstract No. 1287]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):69.

Ono A, Watanabe S, Sugawara t, Wakabayashi K, Tahara Y, Horle N, Fujimoto K, Kusakari K, Kurokawa Y, Sozu T, Nakayama T, Kusao T, Kawakami T, Kojima K, Kojima H, Richmond J, Kleinstreuer N, Bae-Hwa K, Yamamoto Y, Fujita M, Kasahara T. 2018. A multi-centre validation study of amino acid derivative reactivity assay (ADRA): a novel in chemico alternative test method for skin sensitization [Abstract No. 3070]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):500.

Padilla S, Waalkes M, Hunter DL, Hedge J, Jarema K. 2019. Assessing the developmental toxicity and developmental neurotoxicity of 26 organophosphorus pesticides using a zebrafish (Danio rerio) larval assay [Abstract No. 1379]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):91.

Palmer JA, Burrier RE, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer NC. 2018. A human pluripotent stem cell-based assay accurately predicts the developmental toxicity potency for a series of valproate analogues. Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Palmer J, Smith A, Burrier R, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer N. 2018. Valproate analogue developmental toxicity potency in a human pluripotent stem cell-based assay is concordant with in vivo potency [Abstract No. 3262]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):546.

Perkins E, Burgoon L, Garcia-Reyero N, Gearhart JM, McAtee M, Ott D, Pangburn H, Reinke E, Stolle L. 2019. Development of a joint DOD roadmap to promote the use of new approach methodologies in rapid chemical hazard assessment [Abstract No. 2795]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):423.

Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. 2019. Assessment of neurotoxic potential of 90 blinded compounds using zebrafish embryos [Abstract No. 1376]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):90.

Ramaiahgari SC, Auerbach SS, Saddler TO, DeVito MJ, Merrick AB, Paules RS, Ferguson SS. 2019. 3D hepatocyte spheroid models in high-throughput transcriptomics and benchmark concentration analysis for predictive liver toxicology screening [Abstract No. 2622]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):382.

Ramaiahgari SC, Saddler T, Waidyanatha S, Dixon D, Sipes NS, Merrick AB, Rice JR, Dunlap PE, DeVito MJ, Paules RS, Auerbach SS, Ferguson SS. 2018. Functional characterization of human and rat 3D hepatocyte models and application of high-throughput transcriptomics (S1500+) in toxicology screening [Abstract No. 3154]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):521.

Reinke EN, Adams VH, Eck WS. 2018. Prediction of skin sensitization potential in compounds of military interest by in vitro methodologies [Abstract No. 3146]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):519.

Ruiz P, Emond C, Mumtaz M. 2019. Gaining insights to molecular mechanisms of combined air pollutants exposures using PBPK models and systems biology approaches [Abstract No. 1827]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):194.

Ryan KR, Hsieh JH, Parham F, Shapiro A, Sipes N, Collins B, Maull E, Paules RS, Walker N, Behl M. 2018. Strategies and advancements to evaluate developmental neurotoxicity at the National Toxicology Program. Presented at the 58th Annual Meeting of the Teratology Society; Clearwater, FL; 23-27 June 2018.

Schaefer H, Fitzpatrick S, Flannery B. 2019. Chemical contaminants in children's foods: a review of recent literature [Abstract No. 2640]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):386.

Sedykh A, Choksi N, Allen D, Kleinstreuer N, Casey W, Shah RR. 2019. Mixture-based modeling of chemical ocular toxicity based on US EPA hazard categories [Abstract No. 3401]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(S1):60.

Shah I, Harrill J, Setzer RW, Haggard D, Karmaus A, Martin MT, Thomas RS. 2018. Predicting chemical mechanisms-of-action using high-throughput transcriptomic data [Abstract No. 2507]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):367.

Sipes N. 2019. Parsimonious selection of cell lines to reproduce phenotypic variability [Abstract No. 3223]. Presented at the 58th Annual Meeting of the Society of Toxicology; Baltimore; 10-14 March 2019. Toxicol Sci/Toxicologist. 168(1):499.

Sipes NS, Huang R, Shockley K, Martin MT, Shapiro A, Addington J, Auerbach S, Paules R, Judson R, Houck K, Hong H, Hsieh J. 2018. Confidence in fitting and hitting concentration-response data: Tox21 10K library pipeline comparison [Abstract No. 2508]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):367.

Strickland J, Gordon J, Hettick J, Law B, Petersen EJ, Solomotis N, Truax J, Uhl R, Yourick J, Allen D, Kleinstreuer N. 2018. Phase 1 validation of the electrophilic allergen screening assay. Presented at the Seventh Annual Meeting of the American Society for Cellular and Computational Toxicology; Bethesda, MD; 11 September 2018.

Tao J, Kelgwin T, Lowit A. 2018. Reduce animal use for acute toxicity in U.S. EPA pesticide programs [Abstract No. 1639]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):156.

van de Water B, Niemeiger M, Huppelschoten S, den Hollander W, Paules R, Richert L. 2018. High-throughput transcriptomics to dissect the inter-individual variability of the unfolded protein response activation using a large panel of primary human hepatocytes [Abstract No. 1313]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):75.

Wynder J, Ovesen J, Maier A, Judson R, Kleinstreuer N, Krishnan M. 2018. Evaluating the applicability of read-across tools and high-throughput screening data for food relevant chemicals [Abstract No. 1613]. Presented at the 57th Annual Meeting of the Society of Toxicology; San Antonio, TX; 11-15 March 2018. Toxicol Sci/Toxicologist. 150(1):150.

Articles in the NIEHS Environmental Factor newsletter

Kelly C. March 2019. MOU aims to improve cardiovascular safety of pharmaceuticals. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/3/science-highlights/cardiovascular/index.htm

Scruggs S. June 2019. The National Toxicology Program converges on cancer. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/6/science-highlights/cancer/index.htm

Sprankle C. February 2018. Roadmap to guide progress toward replacing animal use. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/2/science-highlights/roadmap/index.htm

Sprankle C. May 2018. Advancing computer models that predict toxicity. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/5/science-highlights/toxicity/index.htm

Sprankle C. June 2018. NTP promotes international use of nonanimal test methods. Environmental Factor [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/6/science-highlights/nonanimal/index.htm

Sprankle C. July 2018. Plan to reduce animal testing showcased at public forum [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/7/science-highlights/animal_testing/index.htm

Sprankle C. September 2018. Replacing animal testing – progress and challenges [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/9/science-highlights/nonanimal/index.htm

Sprankle C. October 2018. Regulators play key roles in replacing animals in tox testing [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/10/science-highlights/toxicity_testing/index.htm

Sprankle C. December 2018. Building confidence in new scientific methods challenges researchers [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/12/science-highlights/new-methods/index.htm

Sprankle C. February 2019. SOT honors computational, nonanimal testing pioneer [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/2/awards-recognition/sot-awards/index.htm

Sprankle C. June 2019. New website tool helps replace animal tests [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/6/science-highlights/ice/index.htm

Sprankle C. July 2019. Fruitful partnerships advance alternatives to animal testing [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/7/science-highlights/fruitful/index.htm

Sprankle C. November 2019. Experts debate challenges of tissue chips, machine learning [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2019/11/science-highlights/animal-testing/index.htm

Weaver J. July 2018. Web resources could assist chemical management [Internet]. [cited 25 Mar 2020] Available from: https://factor.niehs.nih.gov/2018/7/science-highlights/chemical_risk/index.htm