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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Lung-on-a-chip Models to Assess Toxicity of Aerosols

AFRL has developed in vitro lung modeling tools, including lung-on-a-chip models, to enable robust toxicological assessments of aerosolized particulates. These models include technologies to aerosolize, characterize, and monitor dosimetry in real time. They also provide the control necessary to reproduce operational exposure conditions. The lung-on-a-chip models have cyclical stretch capability, simulating the mechanics of breathing, which has been shown to be important in the exposure mechanism. Together, these models and tools provide a platform to assess operationally relevant environmental or engineer toxicant exposures.