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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods


AOPXplorer is a tool to visualize non-animal assay data, mRNA levels, protein expression, and molecular biology data within an AOP network. The networks in AOPXplorer are built by U.S. Army scientists and the user community and are typically based on disease pathways and known modes of action for chemicals. During 2018 and 2019, several new pathways in AOPXplorer were developed and updated, including steatosis, signal transduction, regenerative proliferation, learning memory and cognitive decline, general cancer pathway, estrogen-mediated breast cancer pathway, PPAR-gamma lung fibrosis pathway, steroidogenesis, and skin sensitization. As of January 2020, AOPXplorer has been downloaded over 950 times. AOPXplorer is an app for the Cytoscape network visualization software and can be downloaded from the Cytoscape app store. Submissions of new pathways to AOPXplorer are welcomed.