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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

ICE Tools for IVIVE and Chemical Characterization

NICEATM created the Integrated Chemical Environment (ICE) to provide curated data and tools to facilitate the safety assessment of chemicals. Launched in 2017, ICE addresses the data needs frequently expressed by NICEATM stakeholders. The May 2019 ICE 2.0 update provided a new user interface to simplify searches and new tools that let users explore chemical properties and toxicity in more detail. Tools provided in the update included:

  • An update of the IVIVE tool (Casey et al. 2018) to provide more complex models, including those from EPA's high-throughput toxicokinetic (httk) package, that can improve prediction accuracy.
  • Chemical list characterization to explore physicochemical properties of chemical sets.