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ICCVAM Biennial Report 2018-2019

ICCVAM Biennial Report 2018-2019
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https://ntp.niehs.nih.gov/go/892418

Pred-Skin Web Portal for Predicting Human Skin Sensitizers

In collaboration with scientists at the University of North Carolina at Chapel Hill and the Universidade Federal de Goiás, NICEATM scientists contributed to the development of a model to predict skin sensitization potential of chemicals for two assays, human patch test and murine local lymph node assay, and implemented this model in a web portal (Braga et al. 2017). Work over the last two years focused on substantially revising and expanding the freely available web tool, Pred-Skin version 3.0, to integrate multiple QSAR models developed with in vitro, animal in vivo, and human ex vivo data into a consensus naïve Bayes model that predicts human effects. All models are freely accessible through the Pred-Skin v. 3.0 portal. A publication is being drafted for submission in 2020.

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