U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.


ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Machine Learning Approaches to Assess New Threat Compounds

CCDC CBC is actively investigating machine learning approaches to assess new threat compounds. Specifically, the center is focused on three major initiatives focused on characterizing the toxicity of emerging threat compounds. These include:

  • Regression/classification models for assessing acute toxicity in non-human species.
  • Prediction of chemical targets using available in vitro data on human cell systems.
  • Prediction of chemical-target interaction with three-dimensional docking models.