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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/884120

Extraction and Annotation of Legacy Developmental Toxicity Study Data

To support the evaluation of non-animal approaches for developmental toxicity assessment, NICEATM scientists extracted information from about 250 NTP legacy prenatal developmental toxicity animal studies and a subset of about 50 studies submitted to ECHA that were deemed high-quality by NTP subject matter experts. Study details extracted included species, strain, administration route, dosing duration, and treatment related effects. Efforts are underway to standardize the effects extractions by applying controlled vocabularies and ontologies to facilitate computational analyses and integration with other structured databases such as EPA’s ToxRefDB. 

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