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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Integrated Chemical Environment Updates

NICEATM's Integrated Chemical Environment (ICE) provides data and tools to help develop, assess, and interpret chemical safety tests. An update of ICE was launched in May 2019 that provides a home page with links to all ICE tools and detailed user guides. An update of the Search tool simplified access to chemical information, and tools were added for IVIVE and chemical characterization.

Other data updates to ICE during 2018 and 2019:

  • Expanded physicochemical property predictions to include over 720,000 chemicals using an updated set of predictive models (Mansouri et al. 2018).
  • Updated the curated HTS data coming from the Tox21 initiative to include increased curation and the most up-to-date data release.
  • Added predictions of endocrine activity using the CERAPP (Mansouri et al. 2016) and CoMPARA (Mansouri et al. 2020) models.