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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Establishment of Ontologies for Zebrafish Developmental Toxicity Screening Studies

NICEATM is coordinating collaborative projects to establish ontologies for zebrafish screening. Three laboratories tested the same 90-chemical set using similar study designs and morphology assessments. Data from these studies are being curated and assessed to refine testing approaches and support development of informatics resources. A poster describing this project (Ceger et al.) was presented at the 2019 annual meeting of the Society for Birth Defects Research and Prevention (formerly the Teratology Society).

To further define ontologies for zebrafish screening, NICEATM coordinated an online evaluation of heterogeneity in terms used to describe zebrafish phenotypes following chemical exposure. Zebrafish images were posted online for researchers to evaluate the phenotypes using their in-lab terminology. Results were collected, compiled, and terms mapped to the Zebrafish Phenotype Ontology. A second online evaluation is scheduled for early 2020 and will employ controlled vocabulary; results of this evaluation will be presented in a NICEATM webinar and published.