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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Publication of Paper Outlining Agency Testing Needs in Acute Systemic Toxicity

Understanding the current regulatory use and acceptance of non-animal data is a necessary starting point for future method development, optimization, and validation efforts. Therefore, the ICCVAM Acute Toxicity Workgroup reviewed (Strickland et al. 2018) acute systemic toxicity testing requirements for six U.S. agencies and noted whether there is flexibility in satisfying data needs with methods that replace or reduce animal use. The review informed the development of the Strategic Roadmap for implementing non-animal approaches to assess potential hazards associated with acute exposures to industrial chemicals and medical products.