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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Request for Information on Developmental Toxicity Assays

Developmental toxicity tests evaluate the extent to which exposure to a substance can interfere with normal development. This testing is required by multiple regulatory agencies and uses large numbers of animals. In a May 2018 Federal Register notice (83 FR 20082), NICEATM requested available data and information on approaches and/or technologies currently used to identify potential developmental toxicants. Submitted information has been used to assess the state of the science for these approaches and technologies and determine technical needs for approaches to assess this endpoint.